ID   1.8.4.11
DE   peptide-methionine (S)-S-oxide reductase.
AN   methionine S-oxide reductase.
AN   methionine S-oxide reductase (S-form oxidizing).
AN   methionine sulfoxide reductase.
AN   methionine sulfoxide reductase A.
AN   methionine sulphoxide reductase A.
AN   peptide Met(O) reductase.
AN   peptide methionine sulfoxide reductase.
CA   (1) [thioredoxin]-disulfide + H2O + L-methionyl-[protein] =
CA   [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein].
CA   (2) [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol
CA   + L-methionine (S)-S-oxide.
CC   -!- The reaction occurs in the reverse direction to that shown above.
CC   -!- Exhibits high specificity for the reduction of the S-form of
CC       L-methionine S-oxide, acting faster on the residue in a peptide than
CC       on the free amino acid.
CC   -!- On the free amino acid, it can also reduce D-methionine (S)-S-oxide
CC       but more slowly.
CC   -!- Plays a role in preventing oxidative-stress damage caused by reactive
CC       oxygen species by reducing the oxidized form of methionine back to
CC       methionine and thereby reactivating peptides that had been damaged.
CC   -!- The reaction proceeds via a sulfenic-acid intermediate.
CC   -!- Formerly EC 1.8.4.6.
DR   P0A3Q9, MSAB1_STRPN;  P0A3R0, MSAB1_STRR6;  P65443, MSAB2_STRPN;
DR   P65444, MSAB2_STRR6;  Q7XUP7, MSR21_ORYSJ;  Q7XUP6, MSR22_ORYSJ;
DR   Q9FKF7, MSRA1_ARATH;  Q9A9I6, MSRA1_CAUVC;  Q9CFC8, MSRA1_LACLA;
DR   Q8YXZ4, MSRA1_NOSS1;  Q98JV5, MSRA1_RHILO;  Q92SY7, MSRA1_RHIME;
DR   Q7UJK0, MSRA1_RHOBA;  P0A084, MSRA1_STAA8;  P0A081, MSRA1_STAAM;
DR   P0A082, MSRA1_STAAN;  Q6GH44, MSRA1_STAAR;  Q6G9J8, MSRA1_STAAS;
DR   P0A083, MSRA1_STAAW;  P72622, MSRA1_SYNY3;  Q9LY15, MSRA2_ARATH;
DR   Q9A9E9, MSRA2_CAUVC;  Q9CE42, MSRA2_LACLA;  Q8YWD8, MSRA2_NOSS1;
DR   Q98DV6, MSRA2_RHILO;  Q92LI5, MSRA2_RHIME;  Q7UJI2, MSRA2_RHOBA;
DR   P0A086, MSRA2_STAA8;  P65445, MSRA2_STAAM;  P65446, MSRA2_STAAN;
DR   Q6GGY3, MSRA2_STAAR;  Q6G9D7, MSRA2_STAAS;  P0A085, MSRA2_STAAW;
DR   P72800, MSRA2_SYNY3;  Q9LY14, MSRA3_ARATH;  Q92Y45, MSRA3_RHIME;
DR   P54150, MSRA4_ARATH;  Q336R9, MSRA4_ORYSJ;  Q9SL43, MSRA5_ARATH;
DR   Q5VPG8, MSRA5_ORYSJ;  Q9AL99, MSRAB_AGGAC;  Q93KF3, MSRAB_CAMFE;
DR   P86890, MSRAB_ENTFL;  P45213, MSRAB_HAEIN;  Q9ZMK8, MSRAB_HELPJ;
DR   O25011, MSRAB_HELPY;  P14930, MSRAB_NEIGO;  Q9JWM8, MSRAB_NEIMA;
DR   Q9K1N8, MSRAB_NEIMB;  Q9LAM9, MSRAB_STRGC;  Q99YT1, MSRAB_STRP1;
DR   P0DC40, MSRAB_STRP3;  Q5XAX5, MSRAB_STRP6;  Q8P046, MSRAB_STRP8;
DR   P0DC41, MSRAB_STRPQ;  O83641, MSRAB_TREPA;  Q9KLX6, MSRAB_VIBCH;
DR   B7H0P7, MSRA_ACIB3 ;  B7I4T7, MSRA_ACIB5 ;  B2I399, MSRA_ACIBC ;
DR   B0VL72, MSRA_ACIBS ;  A3M1W6, MSRA_ACIBT ;  B0V4P7, MSRA_ACIBY ;
DR   C1F1B8, MSRA_ACIC5 ;  Q7D255, MSRA_AGRFC ;  A6TUE9, MSRA_ALKMQ ;
DR   A0JXQ4, MSRA_ARTS2 ;  A8IPQ8, MSRA_AZOC5 ;  C1DGW5, MSRA_AZOVD ;
DR   Q65ID1, MSRA_BACLD ;  A8FEA4, MSRA_BACP2 ;  P54154, MSRA_BACSU ;
DR   A7Z5S2, MSRA_BACVZ ;  P54149, MSRA_BOVIN ;  P54151, MSRA_BRANA ;
DR   B2SC53, MSRA_BRUA1 ;  Q2YJM1, MSRA_BRUA2 ;  A6WYH5, MSRA_BRUA4 ;
DR   Q576P8, MSRA_BRUAB ;  Q93S39, MSRA_BRUAN ;  A9MCZ5, MSRA_BRUC2 ;
DR   C0RMK6, MSRA_BRUMB ;  Q8YDE7, MSRA_BRUME ;  A5VVX1, MSRA_BRUO2 ;
DR   A9WW77, MSRA_BRUSI ;  Q8FUZ0, MSRA_BRUSU ;  A8FL58, MSRA_CAMJ8 ;
DR   A7H4H5, MSRA_CAMJD ;  Q9PHN0, MSRA_CAMJE ;  A1VYZ7, MSRA_CAMJJ ;
DR   Q5HVD4, MSRA_CAMJR ;  Q7NVL7, MSRA_CHRVO ;  A5CQY7, MSRA_CLAM3 ;
DR   B0RBB1, MSRA_CLAMS ;  Q97MV3, MSRA_CLOAB ;  A7FUX9, MSRA_CLOB1 ;
DR   C3KXI0, MSRA_CLOB6 ;  A5I348, MSRA_CLOBH ;  C1FPF1, MSRA_CLOBJ ;
DR   B1IMT7, MSRA_CLOBK ;  A7GEN6, MSRA_CLOBL ;  B1KU02, MSRA_CLOBM ;
DR   Q0TM63, MSRA_CLOP1 ;  Q8XH97, MSRA_CLOPE ;  Q0SPW9, MSRA_CLOPS ;
DR   Q899M3, MSRA_CLOTE ;  Q6NEL2, MSRA_CORDI ;  Q8FLU6, MSRA_COREF ;
DR   A4QHY3, MSRA_CORGB ;  Q8NLL5, MSRA_CORGL ;  C4LG69, MSRA_CORK4 ;
DR   Q9APY4, MSRA_CORML ;  A7MM56, MSRA_CROS8 ;  Q9RTB6, MSRA_DEIRA ;
DR   Q9ZEQ8, MSRA_DICD3 ;  Q551H3, MSRA_DICDI ;  P08761, MSRA_DROME ;
DR   A7ZV98, MSRA_ECO24 ;  B7UQN3, MSRA_ECO27 ;  B7MLN1, MSRA_ECO45 ;
DR   B7LCT1, MSRA_ECO55 ;  Q8XCG3, MSRA_ECO57 ;  B5Z3H5, MSRA_ECO5E ;
DR   B7NUD2, MSRA_ECO7I ;  B7MTA1, MSRA_ECO81 ;  B7M9I1, MSRA_ECO8A ;
DR   C4ZR95, MSRA_ECOBW ;  B1XDW8, MSRA_ECODH ;  A8A7X5, MSRA_ECOHS ;
DR   Q0T9G6, MSRA_ECOL5 ;  Q8FAG4, MSRA_ECOL6 ;  B1ISY2, MSRA_ECOLC ;
DR   P0A744, MSRA_ECOLI ;  B7NGF6, MSRA_ECOLU ;  B6I2D2, MSRA_ECOSE ;
DR   B1LRA3, MSRA_ECOSM ;  A4W5V5, MSRA_ENT38 ;  B2VHZ5, MSRA_ERWT9 ;
DR   B7LMP0, MSRA_ESCF3 ;  P54152, MSRA_FRAAN ;  A8L177, MSRA_FRASN ;
DR   Q39Z11, MSRA_GEOMG ;  Q747V4, MSRA_GEOSL ;  Q0BPD5, MSRA_GRABC ;
DR   Q9KAN8, MSRA_HALH5 ;  B0R518, MSRA_HALS3 ;  Q9HQG0, MSRA_HALSA ;
DR   Q18J40, MSRA_HALWD ;  Q7VI69, MSRA_HELHP ;  Q9UJ68, MSRA_HUMAN ;
DR   B5Y2Y3, MSRA_KLEP3 ;  A9KPX7, MSRA_LACP7 ;  Q9SEC2, MSRA_LACSA ;
DR   Q38XB4, MSRA_LATSS ;  Q6AG94, MSRA_LEIXX ;  Q04PP8, MSRA_LEPBJ ;
DR   Q055M2, MSRA_LEPBL ;  Q03W54, MSRA_LEUMM ;  Q1WU33, MSRA_LIGS1 ;
DR   A5VKT1, MSRA_LIMRD ;  Q92AE8, MSRA_LISIN ;  C1KWF9, MSRA_LISMC ;
DR   Q71YF6, MSRA_LISMF ;  B8DDP2, MSRA_LISMH ;  Q8Y640, MSRA_LISMO ;
DR   A0AJW5, MSRA_LISW6 ;  Q2W5W8, MSRA_MAGSA ;  Q8EVK2, MSRA_MALP2 ;
DR   Q0ATD8, MSRA_MARMM ;  B3PND9, MSRA_META1 ;  Q8TQV6, MSRA_METAC ;
DR   Q12TP4, MSRA_METBU ;  Q602T2, MSRA_METCA ;  Q2FQ35, MSRA_METHJ ;
DR   A4FYX5, MSRA_METM5 ;  A9AB97, MSRA_METM6 ;  A6VFD6, MSRA_METM7 ;
DR   Q8PUD6, MSRA_METMA ;  A3CUG3, MSRA_METMJ ;  Q6LYY1, MSRA_METMP ;
DR   B8IJD1, MSRA_METNO ;  B0UCG5, MSRA_METS4 ;  O26635, MSRA_METTH ;
DR   Q9D6Y7, MSRA_MOUSE ;  P0A5L1, MSRA_MYCBO ;  A1KEV7, MSRA_MYCBP ;
DR   C1AJG2, MSRA_MYCBT ;  P47648, MSRA_MYCGE ;  A4T413, MSRA_MYCGI ;
DR   B8ZTJ5, MSRA_MYCLB ;  Q9CCZ3, MSRA_MYCLE ;  B2HLR5, MSRA_MYCMM ;
DR   Q73U14, MSRA_MYCPA ;  P75188, MSRA_MYCPN ;  Q98PE5, MSRA_MYCPU ;
DR   A3Q7V7, MSRA_MYCSJ ;  A1UNG1, MSRA_MYCSK ;  Q1B1N8, MSRA_MYCSS ;
DR   A5TYL2, MSRA_MYCTA ;  P9WJM4, MSRA_MYCTO ;  P9WJM5, MSRA_MYCTU ;
DR   A0PWH2, MSRA_MYCUA ;  A1TH24, MSRA_MYCVP ;  Q3IUS0, MSRA_NATPD ;
DR   B9LA36, MSRA_NAUPA ;  A6Q418, MSRA_NITSB ;  Q3SU08, MSRA_NITWN ;
DR   Q5YUS0, MSRA_NOCFA ;  A1R7D2, MSRA_PAEAT ;  Q9CN40, MSRA_PASMU ;
DR   Q6D151, MSRA_PECAS ;  C6DDM6, MSRA_PECCP ;  Q4FP80, MSRA_PELUB ;
DR   Q7MYW1, MSRA_PHOLL ;  Q6LV65, MSRA_PHOPR ;  Q6L2S4, MSRA_PICTO ;
DR   A4SWL6, MSRA_POLAQ ;  Q48CJ2, MSRA_PSE14 ;  B7V3B1, MSRA_PSEA8 ;
DR   Q02EZ9, MSRA_PSEAB ;  Q9HUF1, MSRA_PSEAE ;  B8HA70, MSRA_PSECP ;
DR   Q1I3L0, MSRA_PSEE4 ;  O69761, MSRA_PSEFL ;  A4XPS6, MSRA_PSEMY ;
DR   B0KJ25, MSRA_PSEPG ;  Q88QZ8, MSRA_PSEPK ;  B1JE82, MSRA_PSEPW ;
DR   Q88AI5, MSRA_PSESM ;  Q4ZM24, MSRA_PSEU2 ;  Q4FQB0, MSRA_PSYA2 ;
DR   Q1Q8I3, MSRA_PSYCK ;  A5WC53, MSRA_PSYWF ;  Q8Y1C6, MSRA_RALN1 ;
DR   Q923M1, MSRA_RAT   ;  B6IS04, MSRA_RHOCS ;  Q2RRT3, MSRA_RHORT ;
DR   B7K079, MSRA_RIPO1 ;  A1AWS4, MSRA_RUTMC ;  Q21JK7, MSRA_SACD2 ;
DR   Q97Y45, MSRA_SACS2 ;  B5F3D4, MSRA_SALA4 ;  A8M3K6, MSRA_SALAI ;
DR   A9MEZ2, MSRA_SALAR ;  Q57GH3, MSRA_SALCH ;  B5FSB9, MSRA_SALDC ;
DR   B5R0T7, MSRA_SALEP ;  B5R9G7, MSRA_SALG2 ;  B4TFF2, MSRA_SALHS ;
DR   B4T3H1, MSRA_SALNS ;  Q5PJ81, MSRA_SALPA ;  A9N540, MSRA_SALPB ;
DR   C0Q6H8, MSRA_SALPC ;  B5BKM8, MSRA_SALPK ;  B4TT49, MSRA_SALSV ;
DR   Q8Z150, MSRA_SALTI ;  A4X3E5, MSRA_SALTO ;  Q8ZK71, MSRA_SALTY ;
DR   Q09859, MSRA_SCHPO ;  A8G8X6, MSRA_SERP5 ;  B2TZL3, MSRA_SHIB3 ;
DR   Q31TF9, MSRA_SHIBS ;  Q328B8, MSRA_SHIDS ;  Q0SXG5, MSRA_SHIF8 ;
DR   P0A745, MSRA_SHIFL ;  Q3YUC8, MSRA_SHISS ;  P54153, MSRA_SOLLC ;
DR   Q5HG58, MSRA_STAAC ;  Q3K013, MSRA_STRA1 ;  Q8E434, MSRA_STRA3 ;
DR   Q8DYH1, MSRA_STRA5 ;  Q82I51, MSRA_STRAW ;  Q9EWF7, MSRA_STRCO ;
DR   C0MBS9, MSRA_STRE4 ;  B4U465, MSRA_STREM ;  B1W2P8, MSRA_STRGG ;
DR   Q8DSY4, MSRA_STRMU ;  Q9A149, MSRA_STRP1 ;  P0DC38, MSRA_STRP3 ;
DR   Q5XDH1, MSRA_STRP6 ;  Q8P272, MSRA_STRP8 ;  Q1JD56, MSRA_STRPB ;
DR   Q1JN29, MSRA_STRPC ;  Q1JI75, MSRA_STRPD ;  A2RG28, MSRA_STRPG ;
DR   Q48UX4, MSRA_STRPM ;  P0DC39, MSRA_STRPQ ;  B5XK66, MSRA_STRPZ ;
DR   C0MCD1, MSRA_STRS7 ;  B9DRF3, MSRA_STRU0 ;  Q4J9L3, MSRA_SULAC ;
DR   Q746G0, MSRA_THET2 ;  Q53W34, MSRA_THET8 ;  Q9AJF7, MSRA_THEVU ;
DR   Q119G2, MSRA_TRIEI ;  B1AIS8, MSRA_UREP2 ;  Q9PQK2, MSRA_UREPA ;
DR   B5ZB99, MSRA_UREU1 ;  A5CWI5, MSRA_VESOH ;  A5F587, MSRA_VIBC3 ;
DR   Q9KP30, MSRA_VIBCH ;  C3LRL2, MSRA_VIBCM ;  Q87SW6, MSRA_VIBPA ;
DR   Q8DE84, MSRA_VIBVU ;  Q8PNY8, MSRA_XANAC ;  Q3BX45, MSRA_XANC5 ;
DR   Q4UR77, MSRA_XANC8 ;  B0RUE7, MSRA_XANCB ;  Q8VS50, MSRA_XANCH ;
DR   Q8PCA6, MSRA_XANCP ;  Q2NZR7, MSRA_XANOM ;  B2SQI9, MSRA_XANOP ;
DR   B2I4P8, MSRA_XYLF2 ;  Q9PC45, MSRA_XYLFA ;  B0U2B7, MSRA_XYLFM ;
DR   Q87D27, MSRA_XYLFT ;  P40029, MSRA_YEAST ;  A1JIU0, MSRA_YERE8 ;
DR   A7FMV2, MSRA_YERP3 ;  Q1CBX8, MSRA_YERPA ;  B2K2M6, MSRA_YERPB ;
DR   Q8ZB94, MSRA_YERPE ;  A9R574, MSRA_YERPG ;  Q1CEI4, MSRA_YERPN ;
DR   A4TRL2, MSRA_YERPP ;  Q66F89, MSRA_YERPS ;  B1JML1, MSRA_YERPY ;
//