ENZYME entry: EC 1.8.4.14

Accepted Name
L-methionine (R)-S-oxide reductase.
Alternative Name(s)
Free met-R-(o) reductase.
Free-methionine (R)-S-oxide reductase.
FRMsr.
Reaction catalysed
L-methionine + thioredoxin disulfide + H(2)O <=> L-methionine (R)-S-oxide + thioredoxin
Cofactor(s)
NADPH.
Comment(s)
  • Unlike EC 1.8.4.12 this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate.
  • Differs from EC 1.8.4.13, in that L-methionine (S)-S-oxide is not a substrate.
  • Formerly EC 1.8.4.5.
Cross-references
BRENDA1.8.4.14
EC2PDB1.8.4.14
ExplorEnz1.8.4.14
PRIAM enzyme-specific profiles1.8.4.14
KEGG Ligand Database for Enzyme Nomenclature1.8.4.14
IUBMB Enzyme Nomenclature1.8.4.14
IntEnz1.8.4.14
MEDLINEFind literature relating to 1.8.4.14
MetaCyc1.8.4.14
UniProtKB/Swiss-Prot
P36088, FRMSR_YEAST;  Q802G6, MSB1A_DANRE;  Q3MHL9, MSRB1_BOVIN;  
Q9NZV6, MSRB1_HUMAN;  Q9JLC3, MSRB1_MOUSE;  A1E952, MSRB1_PIG;  
Q5R869, MSRB1_PONAB;  Q52KJ8, MSRB1_RAT;  Q6NW52, MSRB2_DANRE;  
Q9Y3D2, MSRB2_HUMAN;  Q78J03, MSRB2_MOUSE;  Q4FZX5, MSRB2_RAT;  
Q8IXL7, MSRB3_HUMAN;  Q8BU85, MSRB3_MOUSE;  Q5R930, MSRB3_PONAB;  
P76270, MSRC_ECOLI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.4.-
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