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ENZYME entry: EC 1.8.4.15

Accepted Name
Protein dithiol oxidoreductase (disulfide-forming).
Reaction catalysed
A [DsbA protein] carrying a disulfide bond + a [protein] with reduced L-cysteine residues <=> a [DsbA protein] with reduced L-cysteine residues + a [protein] carrying a disulfide bond
Comment(s)
  • DsbA is a periplasmic thiol:disulfide oxidoreductase found in Gram- negative bacteria that promotes protein disulfide bond formation.
  • DsbA contains a redox active disulfide bond that is catalytically transferred via disulfide exchange to a diverse range of newly translocated protein substrates.
  • The protein is restored to the oxidized state by EC 1.8.5.9.
Cross-references
BRENDA1.8.4.15
EC2PDB1.8.4.15
ExplorEnz1.8.4.15
PRIAM enzyme-specific profiles1.8.4.15
KEGG Ligand Database for Enzyme Nomenclature1.8.4.15
IUBMB Enzyme Nomenclature1.8.4.15
IntEnz1.8.4.15
MEDLINEFind literature relating to 1.8.4.15
MetaCyc1.8.4.15
Rhea expert-curated reactions1.8.4.15

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-