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ENZYME entry: EC 1.8.5.3

Accepted Name
Respiratory dimethylsulfoxide reductase.
Alternative Name(s)
Dimethylsulfoxide reductase.
DMSO reductase.
Reaction catalysed
Dimethylsulfide + menaquinone + H(2)O <=> dimethylsulfoxide + menaquinol
Cofactor(s)
Iron-sulfur; Mo-molybdopterin.
Comment(s)
  • The enzyme participates in bacterial electron transfer pathways in which dimethylsulfoxide (DMSO) is the terminal electron acceptor.
  • It is composed of three subunits - DmsA contains a bis(guanylyl molybdopterin) cofactor and a [4Fe-4S] cluster, DmsB is an iron- sulfur protein, and DmsC is a transmembrane protein that anchors the enzyme and accepts electrons from the quinol pool.
  • The electrons are passed through DmsB to DmsA and on to DMSO.
  • The enzyme can also reduce pyridine-N-oxide and trimethylamine N-oxide to the corresponding amines with lower activity.
Cross-references
BRENDA1.8.5.3
EC2PDB1.8.5.3
ExplorEnz1.8.5.3
PRIAM enzyme-specific profiles1.8.5.3
KEGG Ligand Database for Enzyme Nomenclature1.8.5.3
IUBMB Enzyme Nomenclature1.8.5.3
IntEnz1.8.5.3
MEDLINEFind literature relating to 1.8.5.3
MetaCyc1.8.5.3
UniProtKB/Swiss-Prot
P18775, DMSA_ECOLI;  P45004, DMSA_HAEIN;  Q9HR74, DMSA_HALSA;  
Q52675, DSTOR_RHOCA;  Q57366, DSTOR_RHOSH;  

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