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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Respiratory dimethylsulfoxide reductase.
Alternative Name(s)
Dimethylsulfoxide reductase.
DMSO reductase.
Reaction catalysed
Dimethylsulfide + menaquinone + H(2)O <=> dimethylsulfoxide + menaquinol
Iron-sulfur; Mo-molybdopterin.
  • The enzyme participates in bacterial electron transfer pathways in which dimethylsulfoxide (DMSO) is the terminal electron acceptor.
  • It is composed of three subunits - DmsA contains a bis(guanylyl molybdopterin) cofactor and a [4Fe-4S] cluster, DmsB is an iron- sulfur protein, and DmsC is a transmembrane protein that anchors the enzyme and accepts electrons from the quinol pool.
  • The electrons are passed through DmsB to DmsA and on to DMSO.
  • The enzyme can also reduce pyridine-N-oxide and trimethylamine N-oxide to the corresponding amines with lower activity.
PRIAM enzyme-specific profiles1.8.5.3
KEGG Ligand Database for Enzyme Nomenclature1.8.5.3
IUBMB Enzyme Nomenclature1.8.5.3
MEDLINEFind literature relating to
Q52675, DSTOR_RHOCA;  Q57366, DSTOR_RHOSH;  

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