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ENZYME entry: EC 1.8.5.8

Accepted Name
eukaryotic sulfide quinone oxidoreductase.
Alternative Name(s)
SQOR.
Reaction catalysed
a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione
Comment(s)
  • This eukaryotic enzyme, located at the inner mitochondrial membrane, catalyzes the first step in the metabolism of sulfide.
  • While both sulfite and glutathione have been shown to act as sulfane sulfur acceptors in vitro, it is thought that the latter acts as the main acceptor in vivo.
  • The electrons are transferred via FAD and quinones to the electron transfer chain.
  • Unlike the bacterial homolog (EC 1.8.5.4), which repeats the catalytic cycle without releasing the product, producing a polysulfide, the eukaryotic enzyme transfers the persulfide to an acceptor at the end of each catalytic cycle.
Cross-references
BRENDA1.8.5.8
EC2PDB1.8.5.8
ExplorEnz1.8.5.8
PRIAM enzyme-specific profiles1.8.5.8
KEGG Ligand Database for Enzyme Nomenclature1.8.5.8
IUBMB Enzyme Nomenclature1.8.5.8
IntEnz1.8.5.8
MEDLINEFind literature relating to 1.8.5.8
MetaCyc1.8.5.8
Rhea expert-curated reactions1.8.5.8
UniProtKB/Swiss-Prot
Q54DK1, SQOR_DICDI;  Q9Y6N5, SQOR_HUMAN;  Q9R112, SQOR_MOUSE;  

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