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ENZYME entry: EC 1.8.5.8
Accepted Name |
eukaryotic sulfide quinone oxidoreductase.
|
Alternative Name(s) |
SQOR. |
Reaction catalysed |
a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione |
Comment(s) |
- This eukaryotic enzyme, located at the inner mitochondrial membrane,
catalyzes the first step in the metabolism of sulfide.
- While both sulfite and glutathione have been shown to act as sulfane
sulfur acceptors in vitro, it is thought that the latter acts as the
main acceptor in vivo.
- The electrons are transferred via FAD and quinones to the electron
transfer chain.
- Unlike the bacterial homolog (EC 1.8.5.4), which repeats the
catalytic cycle without releasing the product, producing a
polysulfide, the eukaryotic enzyme transfers the persulfide to an
acceptor at the end of each catalytic cycle.
|
Cross-references |
BRENDA | 1.8.5.8 |
EC2PDB | 1.8.5.8 |
ExplorEnz | 1.8.5.8 |
PRIAM enzyme-specific profiles | 1.8.5.8 |
KEGG Ligand Database for Enzyme Nomenclature | 1.8.5.8 |
IUBMB Enzyme Nomenclature | 1.8.5.8 |
IntEnz | 1.8.5.8 |
MEDLINE | Find literature relating to 1.8.5.8 |
MetaCyc | 1.8.5.8 |
Rhea expert-curated reactions | 1.8.5.8 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.8.5.-
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