Home  |  Contact
Due to scheduled maintenance work, this service will not be available from Tuesday August 23rd 06:00 pm until Wednesday August 24th 08:00 am CEST. Apologies for the inconvenience.

ENZYME entry: EC

Accepted Name
eukaryotic sulfide quinone oxidoreductase.
Alternative Name(s)
Reaction catalysed
a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione
  • This eukaryotic enzyme, located at the inner mitochondrial membrane, catalyzes the first step in the metabolism of sulfide.
  • While both sulfite and glutathione have been shown to act as sulfane sulfur acceptors in vitro, it is thought that the latter acts as the main acceptor in vivo.
  • The electrons are transferred via FAD and quinones to the electron transfer chain.
  • Unlike the bacterial homolog (EC, which repeats the catalytic cycle without releasing the product, producing a polysulfide, the eukaryotic enzyme transfers the persulfide to an acceptor at the end of each catalytic cycle.
PRIAM enzyme-specific profiles1.8.5.8
KEGG Ligand Database for Enzyme Nomenclature1.8.5.8
IUBMB Enzyme Nomenclature1.8.5.8
MEDLINEFind literature relating to
Rhea expert-curated reactions1.8.5.8

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-