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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Eukaryotic sulfide quinone oxidoreductase.
Alternative Name(s)
Reaction catalysed
Hydrogen sulfide + glutathione + a quinone <=> S-sulfanylglutathione + a quinol
  • This eukaryotic enzyme, located at the inner mitochondrial membrane, catalyzes the first step in the metabolism of sulfide.
  • While both sulfite and glutathione have been shown to act as sulfane sulfur acceptors in vitro, it is thought that the latter acts as the main acceptor in vivo.
  • The electrons are transferred via FAD and quinones to the electron transfer chain.
  • Unlike the bacterial homolog (EC, which repeats the catalytic cycle without releasing the product, producing a polysulfide, the eukaryotic enzyme transfers the persulfide to an acceptor at the end of each catalytic cycle.
PRIAM enzyme-specific profiles1.8.5.8
KEGG Ligand Database for Enzyme Nomenclature1.8.5.8
IUBMB Enzyme Nomenclature1.8.5.8
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