ENZYME entry: EC 18.104.22.168
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|Eukaryotic sulfide quinone oxidoreductase.
|Hydrogen sulfide + glutathione + a quinone <=> S-sulfanylglutathione + a quinol|
- This eukaryotic enzyme, located at the inner mitochondrial membrane,
catalyzes the first step in the metabolism of sulfide.
- While both sulfite and glutathione have been shown to act as sulfane
sulfur acceptors in vitro, it is thought that the latter acts as the
main acceptor in vivo.
- The electrons are transferred via FAD and quinones to the electron
- Unlike the bacterial homolog (EC 22.214.171.124), which repeats the
catalytic cycle without releasing the product, producing a
polysulfide, the eukaryotic enzyme transfers the persulfide to an
acceptor at the end of each catalytic cycle.
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
entries corresponding to 1.8.5.-
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