A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.8.5.8
| Accepted Name |
|---|
| Eukaryotic sulfide quinone oxidoreductase.
|
| Alternative Name(s) |
|---|
| SQOR. |
| Reaction catalysed |
|---|
| Hydrogen sulfide + glutathione + a quinone <=> S-sulfanylglutathione + a quinol |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- This eukaryotic enzyme, located at the inner mitochondrial membrane,
catalyzes the first step in the metabolism of sulfide.
- While both sulfite and glutathione have been shown to act as sulfane
sulfur acceptors in vitro, it is thought that the latter acts as the
main acceptor in vivo.
- The electrons are transferred via FAD and quinones to the electron
transfer chain.
- Unlike the bacterial homolog (EC 1.8.5.4), which repeats the
catalytic cycle without releasing the product, producing a
polysulfide, the eukaryotic enzyme transfers the persulfide to an
acceptor at the end of each catalytic cycle.
|
| Cross-references |
|---|
| BRENDA | 1.8.5.8 |
| EC2PDB | 1.8.5.8 |
| ExplorEnz | 1.8.5.8 |
| PRIAM enzyme-specific profiles | 1.8.5.8 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.8.5.8 |
| IUBMB Enzyme Nomenclature | 1.8.5.8 |
| IntEnz | 1.8.5.8 |
| MEDLINE | Find literature relating to 1.8.5.8 |
| MetaCyc | 1.8.5.8 |
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All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.8.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-