ID 1.8.98.5 DE H2:CoB-CoM heterodisulfide,ferredoxin reductase. CA coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = CA coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]- CA [ferredoxin]. CC -!- This enzyme complex is found in H2-oxidizing CO2-reducing CC methanogenic archaea such as Methanothermobacter thermautotrophicus. CC -!- It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD CC hydrogenase. CC -!- Electron pairs donated by the hydrogenase are transferred via its CC Delta subunit to the HdrA subunit of the reductase, where they are CC bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. CC -!- The reductase can also form a similar complex with formate CC dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM CC heterodisulfide,ferredoxin reductase. cf. EC 1.8.7.3, EC 1.8.98.4, CC and EC 1.8.98.1. DR Q6LWL2, HDRA_METMP ; O27434, HDRA_METTH ; Q50756, HDRA_METTM ; DR Q6LY38, HDRB1_METMP; Q6LYD8, HDRB2_METMP; O27907, HDRB_METTH ; DR Q50755, HDRB_METTM ; Q6LY39, HDRC1_METMP; Q6LYD7, HDRC2_METMP; DR O27906, HDRC_METTH ; Q50754, HDRC_METTM ; //