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ENZYME

ENZYME entry: EC 1.97.1.15

PURL: https://purl.expasy.org/enzyme/EC/1.97.1.15
Accepted Name
2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate)
Reaction catalysed
  • a 2-(all-trans-polyprenyl)phenol + prephenate + A + H(+) = a 3-(all-trans-polyprenyl)benzene-1,2-diol + 3-phenylpyruvate + AH2 + CO2
  • a 2-methoxy-6-(all-trans-polyprenyl)phenol + prephenate + A + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 3-phenylpyruvate + AH2 + CO2
  • a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + prephenate + A + H(+) = a 3-demethylubiquinol + 3-phenylpyruvate + AH2 + CO2
Comment(s)
  • The enzyme, characterized from the bacterium Escherichia coli, catalyzes three hydroxylation reactions in the oxygen-independent pathway for ubiquinone (UQ) biosynthesis.
  • The reaction involves an electron acceptor whose identity remains unknown as of 2024.
  • The Escherichia coli enzyme is a heterodimer, with both subunits containing a [4Fe-4S] cluster that is essential for activity and may serve as part of an electron transfer chain from the substrate to the unidentified electron acceptor.
Cross-references
Rhea expert-curated reactions1.97.1.15
ExplorEnz1.97.1.15
IUBMB Enzyme Nomenclature1.97.1.15
UniProtKB/Swiss-Prot
P45527, UBIU_ECOLIP45475, UBIV_ECOLI
BRENDA1.97.1.15
MetaCyc1.97.1.15
KEGG Ligand Database for Enzyme Nomenclature1.97.1.15
EC2PDB1.97.1.15
MEDLINEFind literature relating to 1.97.1.15

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