ID   1.97.1.15
DE   2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate).
CA   (1) a 2-(all-trans-polyprenyl)phenol + prephenate + A + H(+) = a 3-(all-
CA   trans-polyprenyl)benzene-1,2-diol + 3-phenylpyruvate + AH2 + CO2.
CA   (2) a 2-methoxy-6-(all-trans-polyprenyl)phenol + prephenate + A + H(+) =
CA   a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 3-phenylpyruvate +
CA   AH2 + CO2.
CA   (3) a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol +
CA   prephenate + A + H(+) = a 3-demethylubiquinol + 3-phenylpyruvate + AH2 +
CA   CO2.
CC   -!- The enzyme, characterized from the bacterium Escherichia coli,
CC       catalyzes three hydroxylation reactions in the oxygen-independent
CC       pathway for ubiquinone (UQ) biosynthesis.
CC   -!- The reaction involves an electron acceptor whose identity remains
CC       unknown as of 2024.
CC   -!- The Escherichia coli enzyme is a heterodimer, with both subunits
CC       containing a [4Fe-4S] cluster that is essential for activity and may
CC       serve as part of an electron transfer chain from the substrate to the
CC       unidentified electron acceptor.
DR   P45527, UBIU_ECOLI ;  P45475, UBIV_ECOLI ;
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