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ENZYME

ENZYME entry: EC 1.97.1.4

PURL: https://purl.expasy.org/enzyme/EC/1.97.1.4
Accepted Name
[formate-C-acetyltransferase]-activating enzyme
Alternative Name(s)
[pyruvate formate-lyase]-activating enzyme
formate acetyltransferase activating enzyme
formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L- methionine oxidoreductase (S-adenosyl-L-methionine cleaving)
PFL activase
PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving)
pyruvate formate-lyase 1 activating enzyme
Reaction catalysed
glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = glycin-2-yl radical-[formate C-acetyltransferase] + semiquinone [flavodoxin] + 5'-deoxyadenosine + L-methionine + H(+)
Comment(s)
  • A single glycine residue in EC 2.3.1.54 is oxidized to the corresponding radical by transfer of H from its CH2 to AdoMet with concomitant cleavage of the latter.
  • The first stage is reduction of the AdoMet to give methionine and the 5'-deoxyadenosin-5'-yl radical, which then abstracts a hydrogen radical from the glycine residue.
Cross-references
BRENDA1.97.1.4
EC2PDB1.97.1.4
ExplorEnz1.97.1.4
KEGG Ligand Database for Enzyme Nomenclature1.97.1.4
IUBMB Enzyme Nomenclature1.97.1.4
MEDLINEFind literature relating to 1.97.1.4
MetaCyc1.97.1.4
Rhea expert-curated reactions1.97.1.4
UniProtKB/Swiss-Prot
Q46267, PFLA_CLOPAP0A9N6, PFLA_ECO57P0A9N5, PFLA_ECOL6
P0A9N4, PFLA_ECOLIP43751, PFLA_HAEINP0A443, PFLA_LISIN
Q71ZR3, PFLA_LISMFP0A442, PFLA_LISMOP0A9N7, PFLA_SHIFL
Q2FK43, PFLA_STAA3Q2G1D7, PFLA_STAA8Q2YV52, PFLA_STAAB
Q5HJF3, PFLA_STAACQ99WZ6, PFLA_STAAMQ7A7X5, PFLA_STAAN
Q6GK89, PFLA_STAARQ6GCP9, PFLA_STAASQ7A1W8, PFLA_STAAW
Q5HKI0, PFLA_STAEQQ8CTX5, PFLA_STAESO68575, PFLA_STRMU
P32675, PFLC_ECOLIP75794, PFLE_ECOLI

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