ENZYME entry: EC 2.1.1.100
| Accepted Name |
|---|
| protein-S-isoprenylcysteine O-methyltransferase.
|
| Alternative Name(s) |
|---|
| isoprenylcysteine carboxylmethyltransferase. |
| prenylated protein carboxyl methyltransferase. |
| prenylcysteine carboxyl methyltransferase. |
| Reaction catalysed |
|---|
| [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine |
| Comment(s) |
|---|
- C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues
are also methylated, more slowly.
- Formerly EC 2.1.1.24.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.100 |
| EC2PDB | 2.1.1.100 |
| ExplorEnz | 2.1.1.100 |
| PRIAM enzyme-specific profiles | 2.1.1.100 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.100 |
| IUBMB Enzyme Nomenclature | 2.1.1.100 |
| IntEnz | 2.1.1.100 |
| MEDLINE | Find literature relating to 2.1.1.100 |
| MetaCyc | 2.1.1.100 |
| Rhea expert-curated reactions | 2.1.1.100 |
| UniProtKB/Swiss-Prot |
| Q9FMW9, ICMTA_ARATH; | Q93W54, ICMTB_ARATH; | Q558K8, ICMT_DICDI; |
| O60725, ICMT_HUMAN; | Q8TMG0, ICMT_METAC; | Q9EQK7, ICMT_MOUSE; |
| A2XX73, ICMT_ORYSI; | Q7XSR9, ICMT_ORYSJ; | Q9WVM4, ICMT_RAT; |
| D6WJ77, ICMT_TRICA; | O12947, ICMT_XENLA; | P87014, MAM4_SCHPO; |
| P32584, STE14_YEAST; |
|
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