ID   2.1.1.106
DE   tryptophan 2-C-methyltransferase.
CA   L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + H(+) +
CA   S-adenosyl-L-homocysteine.
CC   -!- The enzyme, characterized from the bacterium Streptomyces laurentii,
CC       is involved in thiostrepton biosynthesis.
CC   -!- It is a radical SAM enzyme that contains a [4Fe-4S] center and a
CC       cobalamin cofactor.
CC   -!- The enzyme first transfers the methyl group from SAM to the bound
CC       cobalamin, followed by transfer from methylcobalamin to L-tryptophan,
CC       resulting in retention of the original methyl group configuration.
CC   -!- The second transfer is likely to involve a CH3 radical species formed
CC       from methylcobalamin by the concerted action of a partially ligated
CC       radical SAM [4Fe-4S](2+/1+) center.
DR   C0JRZ9, TSRM_STRLU ;
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