ID   2.1.1.106
DE   tryptophan 2-C-methyltransferase.
AN   tryptophan 2-methyltransferase.
CA   L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan +
CA   S-adenosyl-L-homocysteine + H(+).
CC   -!- The enzyme, characterized from the bacterium Streptomyces laurentii,
CC       is involved in thiostrepton biosynthesis.
CC   -!- It is a radical SAM enzyme that contains a [4Fe-4S] center and a
CC       methylcob(III)alamin cofactor.
CC   -!- It has an exceptional reaction mechanism as the S-adenosyl-L-
CC       methionine (SAM) is not bound to the [4Fe-4S] center and does not
CC       produce a 5'-deoxyadenosyl radical but instead is believed to be
CC       involved in binding of the L-tryptophan substrate.
CC   -!- After transfer of the methyl group from methylcob(III)alaminIn a
CC       methyl transfer from SAM to the generated cob(I)alamin takes place,
CC       preparing the enzyme for the next catalytic cycle.
CC   -!- The original methyl group configuration is preserved.
DR   C0JRZ9, TSRM_STRLU ;
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