ID 2.1.1.133 DE precorrin-4 C(11)-methyltransferase. AN precorrin-3 methylase. AN precorrin-4 C11-methyltransferase. CA precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L- CA homocysteine. CC -!- In the aerobic (late cobalt insertion) cobalamin biosythesis pathway, CC four enzymes are involved in the conversion of precorrin-3A to CC precorrin-6A. CC -!- The first of the four steps is carried out by EC 1.14.13.83 (CobG), CC yielding precorrin-3B as the product. CC -!- This is followed by three methylation reactions, which introduce a CC methyl group at C-17 (CobJ; EC 2.1.1.131), C-11 (CobM; EC 2.1.1.133) CC and C-1 (CobF; EC 2.1.1.152) of the macrocycle, giving rise to CC precorrin-4, precorrin-5, and precorrin-6A, respectively. CC -!- See EC 2.1.1.271 for the C(11)-methyltransferase enzyme that CC participates in the anaerobic cobalamin biosynthesis pathway. DR P9WGB0, COBM_MYCTO ; P9WGB1, COBM_MYCTU ; Q9HZP9, COBM_PSEAE ; DR O68100, COBM_RHOCB ; Q53138, COBM_RHOER ; P21922, COBM_SINSX ; //