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ENZYME entry: EC 2.1.1.137

Accepted Name
Arsenite methyltransferase.
Alternative Name(s)
Methylarsonite methyltransferase.
S-adenosyl-L-methionine:arsenic(III) methyltransferase.
S-adenosyl-L-methionine:methylarsonite As-methyltransferase.
Reaction catalysed
  • S-adenosyl-L-methionine + arsenite <=> S-adenosyl-L-homocysteine + methylarsonate
  • S-adenosyl-L-methionine + methylarsonite <=> S-adenosyl-L-homocysteine + dimethylarsinate
Comment(s)
  • An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate.
  • It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by EC 1.20.4.2 to methylarsonite, Me-As(OH)(2).
  • Methylarsonite is also a substrate for this enzyme which converts it into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.
Cross-references
BRENDA2.1.1.137
EC2PDB2.1.1.137
ExplorEnz2.1.1.137
PRIAM enzyme-specific profiles2.1.1.137
KEGG Ligand Database for Enzyme Nomenclature2.1.1.137
IUBMB Enzyme Nomenclature2.1.1.137
IntEnz2.1.1.137
MEDLINEFind literature relating to 2.1.1.137
MetaCyc2.1.1.137
Rhea expert-curated reactions2.1.1.137
UniProtKB/Swiss-Prot
A0A0D3MJQ5, ARSM_CLOSP;  O52025, ARSM_HALSA;  Q8TJK1, ARSM_METAC;  
U2ZU49, ARSM_PSEA4;  Q6N3Y0, ARSM_RHOPA;  Q9HBK9, AS3MT_HUMAN;  
Q91WU5, AS3MT_MOUSE;  Q8VHT6, AS3MT_RAT;  

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