A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.1.1.137

Accepted Name
Arsenite methyltransferase.
Alternative Name(s)
Methylarsonite methyltransferase.
S-adenosyl-L-methionine:arsenic(III) methyltransferase.
S-adenosyl-L-methionine:methylarsonite As-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + arsenite <=> S-adenosyl-L-homocysteine + methylarsonate S-adenosyl-L-methionine + methylarsonite <=> S-adenosyl-L-homocysteine + dimethylarsinate
Comment(s)
An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by EC 1.20.4.2 to methylarsonite, Me-As(OH)(2). Methylarsonite is also a substrate for this enzyme which converts it into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH.
Cross-references
BRENDA	2.1.1.137
EC2PDB	2.1.1.137
ExplorEnz	2.1.1.137
PRIAM enzyme-specific profiles	2.1.1.137
KEGG Ligand Database for Enzyme Nomenclature	2.1.1.137
IUBMB Enzyme Nomenclature	2.1.1.137
IntEnz	2.1.1.137
MEDLINE	Find literature relating to 2.1.1.137
MetaCyc	2.1.1.137
UniProtKB/Swiss-Prot	A0A0D3MJQ5, ARSM_CLOSP;   O52025, ARSM_HALSA;   Q8TJK1, ARSM_METAC;   U2ZU49, ARSM_PSEA4;   Q6N3Y0, ARSM_RHOPA;   Q9HBK9, AS3MT_HUMAN;   Q91WU5, AS3MT_MOUSE;   Q8VHT6, AS3MT_RAT;

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-