ENZYME entry: EC 2.1.1.137
Accepted Name |
Arsenite methyltransferase.
|
Alternative Name(s) |
Methylarsonite methyltransferase. |
S-adenosyl-L-methionine:arsenic(III) methyltransferase. |
S-adenosyl-L-methionine:methylarsonite As-methyltransferase. |
Reaction catalysed |
- S-adenosyl-L-methionine + arsenite <=> S-adenosyl-L-homocysteine + methylarsonate
- S-adenosyl-L-methionine + methylarsonite <=> S-adenosyl-L-homocysteine + dimethylarsinate
|
Comment(s) |
- An enzyme of the biotransformation pathway that forms
dimethylarsinate from inorganic arsenite and arsenate.
- It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which
is reduced by EC 1.20.4.2 to methylarsonite, Me-As(OH)(2).
- Methylarsonite is also a substrate for this enzyme which converts it
into the much less toxic compound dimethylarsinate (cacodylate),
Me(2)As(O)-OH.
|
Cross-references |
BRENDA | 2.1.1.137 |
EC2PDB | 2.1.1.137 |
ExplorEnz | 2.1.1.137 |
PRIAM enzyme-specific profiles | 2.1.1.137 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.137 |
IUBMB Enzyme Nomenclature | 2.1.1.137 |
IntEnz | 2.1.1.137 |
MEDLINE | Find literature relating to 2.1.1.137 |
MetaCyc | 2.1.1.137 |
Rhea expert-curated reactions | 2.1.1.137 |
UniProtKB/Swiss-Prot |
|
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