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ENZYME entry: EC 2.1.1.139

Accepted Name
3'-demethylstaurosporine O-methyltransferase.
Alternative Name(s)
3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase.
Staurosporine synthase.
Reaction catalysed
S-adenosyl-L-methionine + 3'-demethylstaurosporine <=> S-adenosyl-L-homocysteine + staurosporine
Comment(s)
Catalyzes the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C.
Cross-references
BRENDA2.1.1.139
EC2PDB2.1.1.139
ExplorEnz2.1.1.139
PRIAM enzyme-specific profiles2.1.1.139
KEGG Ligand Database for Enzyme Nomenclature2.1.1.139
IUBMB Enzyme Nomenclature2.1.1.139
IntEnz2.1.1.139
MEDLINEFind literature relating to 2.1.1.139
MetaCyc2.1.1.139
Rhea expert-curated reactions2.1.1.139

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-