ENZYME entry: EC 2.1.1.139
| Accepted Name | |
|---|---|
| 3'-demethylstaurosporine O-methyltransferase | |
| Alternative Name(s) | |
| 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase | |
| staurosporine synthase | |
| Reaction catalysed | |
| 3'-demethylstaurosporine + S-adenosyl-L-methionine = staurosporine + S-adenosyl-L-homocysteine + H(+) | |
| Comment(s) | |
| Catalyzes the final step in the biosynthesis of staurosporine, an alkaloidal antibiotic that is a potent inhibitor of protein kinases, especially protein kinase C. | |
| Cross-references | |
| Rhea expert-curated reactions | 2.1.1.139 |
| ExplorEnz | 2.1.1.139 |
| IUBMB Enzyme Nomenclature | 2.1.1.139 |
| BRENDA | 2.1.1.139 |
| MetaCyc | 2.1.1.139 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.139 |
| MEDLINE | Find literature relating to 2.1.1.139 |
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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