ID 2.1.1.152 DE precorrin-6A synthase (deacetylating). AN precorrin-6X synthase (deacetylating). CA precorrin-5 + S-adenosyl-L-methionine + H2O = precorrin-6A + acetate + CA S-adenosyl-L-homocysteine + 2 H(+). CC -!- The enzyme, which participates in the aerobic (late cobalt insertion) CC cobalamin biosythesis pathway, catalyzes two reactions - the CC methylation of carbon C(1) of precorrin-5, and its deacetylation, CC forming precorrin-6A. CC -!- See EC 2.1.1.195 for the C(1)-methyltransferase that participates in CC the anaerobic cobalamin biosynthesis pathway. DR P21636, COBF_SINSX ; //