ID 2.1.1.158 DE 7-methylxanthosine synthase. AN xanthosine methyltransferase. AN XMT. AN XRS1. CA S-adenosyl-L-methionine + xanthosine = 7-methylxanthosine + S-adenosyl-L- CA homocysteine. CC -!- The enzyme is specific for xanthosine, as XMP and xanthine cannot act CC as substrates. CC -!- The enzyme does not have N(1)- or N(3)- methylation activity. CC -!- This is the first methylation step in the production of caffeine. DR Q9AVK0, XMT1_COFAR ; A4GE69, XMT1_COFCA ; A0A096VHY7, XMT2_COFAR ; //