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ENZYME entry: EC 2.1.1.159

Accepted Name
Theobromine synthase.
Alternative Name(s)
Monomethylxanthine methyltransferase.
MXMT.
Reaction catalysed
S-adenosyl-L-methionine + 7-methylxanthine <=> S-adenosyl-L-homocysteine + 3,7-dimethylxanthine
Comment(s)
  • Can also catalyze the conversion of paraxanthine into caffeine, although the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis.
  • This is the third enzyme in the caffeine biosynthesis pathway.
Cross-references
BRENDA2.1.1.159
EC2PDB2.1.1.159
ExplorEnz2.1.1.159
PRIAM enzyme-specific profiles2.1.1.159
KEGG Ligand Database for Enzyme Nomenclature2.1.1.159
IUBMB Enzyme Nomenclature2.1.1.159
IntEnz2.1.1.159
MEDLINEFind literature relating to 2.1.1.159
MetaCyc2.1.1.159
Rhea expert-curated reactions2.1.1.159
UniProtKB/Swiss-Prot
A0A061FMF5, BTS1_THECC;  A0A061FKL9, BTS2_THECC;  A0A061FTC2, BTS3_THECC;  
A0A061FLA2, BTS4_THECC;  A0A061FKM4, BTS5_THECC;  A0A6C0WX00, CKTBS_CAMSB;  
Q2HXL9, ICS1_CAMIR;  Q9AVJ9, MXMT1_COFAR;  Q4U5S1, MXMT1_COFCA;  
Q84PP7, MXMT2_COFAR;  Q8RVM0, MXMT2_COFCA;  Q2HXI6, PCS1_CAMPL;  
Q2HXI5, PCS2_CAMPL;  

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