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ENZYME entry: EC 2.1.1.160

Accepted Name
caffeine synthase.
Alternative Name(s)
3N-methyltransferase.
dimethylxanthine methyltransferase.
Reaction catalysed
  • S-adenosyl-L-methionine + theobromine <=> caffeine + H(+) + S-adenosyl-L-homocysteine
  • 1,7-dimethylxanthine + S-adenosyl-L-methionine <=> caffeine + H(+) + S-adenosyl-L-homocysteine
  • 7-methylxanthine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theobromine
Comment(s)
Paraxanthine is the best substrate for this enzyme but the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis.
Cross-references
BRENDA2.1.1.160
EC2PDB2.1.1.160
ExplorEnz2.1.1.160
PRIAM enzyme-specific profiles2.1.1.160
KEGG Ligand Database for Enzyme Nomenclature2.1.1.160
IUBMB Enzyme Nomenclature2.1.1.160
IntEnz2.1.1.160
MEDLINEFind literature relating to 2.1.1.160
MetaCyc2.1.1.160
Rhea expert-curated reactions2.1.1.160
UniProtKB/Swiss-Prot
A0A6C0WW38, CKCS_CAMSB;  Q8H0D2, DXMT1_COFAR;  A4GE70, DXMT1_COFCA;  
Q8H0D3, DXMT2_COFAR;  A0A0S2PMA8, TCS1D_CAMTA;  A0A0S2PM92, TCS1F_CAMCR;  
Q9FZN8, TCS1_CAMSI;  Q68CM3, TCS2_CAMSI;  A0A0S2PM82, TCS3_CAMSI;  

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