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ENZYME

ENZYME entry: EC 2.1.1.160

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.160
Accepted Name
caffeine synthase
Alternative Name(s)
3N-methyltransferase
dimethylxanthine methyltransferase
Reaction catalysed
  • theobromine + S-adenosyl-L-methionine = caffeine + S-adenosyl-L-homocysteine + H(+)
  • 1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + S-adenosyl-L-homocysteine + H(+)
  • 7-methylxanthine + S-adenosyl-L-methionine = theobromine + S-adenosyl-L-homocysteine + H(+)
Comment(s)
Paraxanthine is the best substrate for this enzyme but the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis.
Cross-references
BRENDA2.1.1.160
EC2PDB2.1.1.160
ExplorEnz2.1.1.160
KEGG Ligand Database for Enzyme Nomenclature2.1.1.160
IUBMB Enzyme Nomenclature2.1.1.160
MEDLINEFind literature relating to 2.1.1.160
MetaCyc2.1.1.160
Rhea expert-curated reactions2.1.1.160
UniProtKB/Swiss-Prot
A0A6C0WW38, CKCS_CAMSBQ8H0D2, DXMT1_COFARA4GE70, DXMT1_COFCA
Q8H0D3, DXMT2_COFARA0A0S2PMA8, TCS1D_CAMTAA0A0S2PM92, TCS1F_CAMCR
Q9FZN8, TCS1_CAMSIQ68CM3, TCS2_CAMSIA0A0S2PM82, TCS3_CAMSI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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