ENZYME entry: EC 2.1.1.179
| Accepted Name | ||||||||
|---|---|---|---|---|---|---|---|---|
| 16S rRNA (guanine(1405)-N(7))-methyltransferase | ||||||||
| Alternative Name(s) | ||||||||
| sisomicin-gentamicin methyltransferase | ||||||||
| Reaction catalysed | ||||||||
| guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine | ||||||||
| Comment(s) | ||||||||
| The enzyme from the antibiotic-producing bacterium Micromonospora zionensis specifically methylates guanine(1405) at N(7) in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins. | ||||||||
| Cross-references | ||||||||
| BRENDA | 2.1.1.179 | |||||||
| EC2PDB | 2.1.1.179 | |||||||
| ExplorEnz | 2.1.1.179 | |||||||
| PRIAM enzyme-specific profiles | 2.1.1.179 | |||||||
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.179 | |||||||
| IUBMB Enzyme Nomenclature | 2.1.1.179 | |||||||
| IntEnz | 2.1.1.179 | |||||||
| MEDLINE | Find literature relating to 2.1.1.179 | |||||||
| MetaCyc | 2.1.1.179 | |||||||
| Rhea expert-curated reactions | 2.1.1.179 | |||||||
| UniProtKB/Swiss-Prot |
| |||||||
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