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ENZYME entry: EC 2.1.1.180

Accepted Name
16S rRNA (adenine(1408)-N(1))-methyltransferase.
Reaction catalysed
adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine
Comment(s)
The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N(1)-methylation at position adenine(1408).
Cross-references
BRENDA2.1.1.180
EC2PDB2.1.1.180
ExplorEnz2.1.1.180
PRIAM enzyme-specific profiles2.1.1.180
KEGG Ligand Database for Enzyme Nomenclature2.1.1.180
IUBMB Enzyme Nomenclature2.1.1.180
IntEnz2.1.1.180
MEDLINEFind literature relating to 2.1.1.180
MetaCyc2.1.1.180
Rhea expert-curated reactions2.1.1.180
UniProtKB/Swiss-Prot
Q2MEY3, KAMB_STRHI;  P25920, KAMB_STRSD;  A8C927, NPMA_ECOLX;  

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