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ENZYME entry: EC 2.1.1.184
| Accepted Name |
|---|
| 23S rRNA (adenine(2085)-N(6))-dimethyltransferase.
|
| Reaction catalysed |
|---|
| adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine |
| Comment(s) |
|---|
- ErmC is a methyltransferase that confers resistance to the macrolide-
lincosamide-streptogramin B group of antibiotics by catalyzing the
methylation of 23S rRNA at adenine(2085).
- Formerly EC 2.1.1.48.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.184 |
| EC2PDB | 2.1.1.184 |
| ExplorEnz | 2.1.1.184 |
| PRIAM enzyme-specific profiles | 2.1.1.184 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.184 |
| IUBMB Enzyme Nomenclature | 2.1.1.184 |
| IntEnz | 2.1.1.184 |
| MEDLINE | Find literature relating to 2.1.1.184 |
| MetaCyc | 2.1.1.184 |
| Rhea expert-curated reactions | 2.1.1.184 |
| UniProtKB/Swiss-Prot |
| P0A4D6, ERM1_CLOPF; | P0A4D5, ERM1_ENTFL; | P0A0H1, ERMA_STAAM; |
| P0A0H2, ERMA_STAAN; | Q6GKQ0, ERMA_STAAR; | P0A0H3, ERMA_STAAU; |
| P10738, ERMB_ECOLX; | P20173, ERMB_ENTFA; | P02979, ERMC1_STAAU; |
| P13957, ERMC2_STAAU; | P13978, ERMC3_STAAU; | P07287, ERME_SACEN; |
| Q00014, ERMG_LIMRT; | P06572, ERMM_STAEP; | P45439, ERMS_STRFR; |
| P13956, ERM_BACIU; | P21236, ERM_STREE; | P06573, ERM_STRSA; |
|
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UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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