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ENZYME entry: EC 2.1.1.184

Accepted Name
23S rRNA (adenine(2085)-N(6))-dimethyltransferase.
Reaction catalysed
adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine
Comment(s)
  • ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085).
  • Formerly EC 2.1.1.48.
Cross-references
BRENDA2.1.1.184
EC2PDB2.1.1.184
ExplorEnz2.1.1.184
PRIAM enzyme-specific profiles2.1.1.184
KEGG Ligand Database for Enzyme Nomenclature2.1.1.184
IUBMB Enzyme Nomenclature2.1.1.184
IntEnz2.1.1.184
MEDLINEFind literature relating to 2.1.1.184
MetaCyc2.1.1.184
Rhea expert-curated reactions2.1.1.184
UniProtKB/Swiss-Prot
P0A4D6, ERM1_CLOPF;  P0A4D5, ERM1_ENTFL;  P0A0H1, ERMA_STAAM;  
P0A0H2, ERMA_STAAN;  Q6GKQ0, ERMA_STAAR;  P0A0H3, ERMA_STAAU;  
P10738, ERMB_ECOLX;  P20173, ERMB_ENTFA;  P02979, ERMC1_STAAU;  
P13957, ERMC2_STAAU;  P13978, ERMC3_STAAU;  P07287, ERME_SACEN;  
Q00014, ERMG_LIMRT;  P06572, ERMM_STAEP;  P45439, ERMS_STRFR;  
P13956, ERM_BACIU;  P21236, ERM_STREE;  P06573, ERM_STRSA;  

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