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ENZYME entry: EC 2.1.1.184
Accepted Name |
23S rRNA (adenine(2085)-N(6))-dimethyltransferase.
|
Reaction catalysed |
adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine |
Comment(s) |
- ErmC is a methyltransferase that confers resistance to the macrolide-
lincosamide-streptogramin B group of antibiotics by catalyzing the
methylation of 23S rRNA at adenine(2085).
- Formerly EC 2.1.1.48.
|
Cross-references |
BRENDA | 2.1.1.184 |
EC2PDB | 2.1.1.184 |
ExplorEnz | 2.1.1.184 |
PRIAM enzyme-specific profiles | 2.1.1.184 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.184 |
IUBMB Enzyme Nomenclature | 2.1.1.184 |
IntEnz | 2.1.1.184 |
MEDLINE | Find literature relating to 2.1.1.184 |
MetaCyc | 2.1.1.184 |
Rhea expert-curated reactions | 2.1.1.184 |
UniProtKB/Swiss-Prot |
P0A4D6, ERM1_CLOPF; | P0A4D5, ERM1_ENTFL; | P0A0H1, ERMA_STAAM; |
P0A0H2, ERMA_STAAN; | Q6GKQ0, ERMA_STAAR; | P0A0H3, ERMA_STAAU; |
P10738, ERMB_ECOLX; | P20173, ERMB_ENTFA; | P02979, ERMC1_STAAU; |
P13957, ERMC2_STAAU; | P13978, ERMC3_STAAU; | P07287, ERME_SACEN; |
Q00014, ERMG_LIMRT; | P06572, ERMM_STAEP; | P45439, ERMS_STRFR; |
P13956, ERM_BACIU; | P21236, ERM_STREE; | P06573, ERM_STRSA; |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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