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ENZYME

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ENZYME entry: EC 2.1.1.184

Accepted Name
23S rRNA (adenine(2085)-N(6))-dimethyltransferase
Reaction catalysed
adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine
Comment(s)
  • ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085).
  • Formerly EC 2.1.1.48.
Cross-references
BRENDA2.1.1.184
EC2PDB2.1.1.184
ExplorEnz2.1.1.184
PRIAM enzyme-specific profiles2.1.1.184
KEGG Ligand Database for Enzyme Nomenclature2.1.1.184
IUBMB Enzyme Nomenclature2.1.1.184
IntEnz2.1.1.184
MEDLINEFind literature relating to 2.1.1.184
MetaCyc2.1.1.184
Rhea expert-curated reactions2.1.1.184
UniProtKB/Swiss-Prot
P0A4D6, ERM1_CLOPFP0A4D5, ERM1_ENTFLP0A0H1, ERMA_STAAM
P0A0H2, ERMA_STAANQ6GKQ0, ERMA_STAARP0A0H3, ERMA_STAAU
P10738, ERMB_ECOLXP20173, ERMB_ENTFAP02979, ERMC1_STAAU
P13957, ERMC2_STAAUP13978, ERMC3_STAAUP07287, ERME_SACEN
Q00014, ERMG_LIMRTP06572, ERMM_STAEPP45439, ERMS_STRFR
P13956, ERM_BACIUP21236, ERM_STREEP06573, ERM_STRSA

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