Home  |  Contact

ENZYME entry: EC 2.1.1.197

Accepted Name
malonyl-[acyl-carrier protein] O-methyltransferase.
Reaction catalysed
malonyl-[ACP] + S-adenosyl-L-methionine <=> malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine
Comment(s)
  • Involved in an early step of biotin biosynthesis in Gram-negative bacteria.
  • This enzyme catalyzes the transfer of a methyl group to the omega- carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester.
  • The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl- [acyl-carrier-protein] methyl ester.
  • While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein].
Cross-references
BRENDA2.1.1.197
EC2PDB2.1.1.197
ExplorEnz2.1.1.197
PRIAM enzyme-specific profiles2.1.1.197
KEGG Ligand Database for Enzyme Nomenclature2.1.1.197
IUBMB Enzyme Nomenclature2.1.1.197
IntEnz2.1.1.197
MEDLINEFind literature relating to 2.1.1.197
MetaCyc2.1.1.197
Rhea expert-curated reactions2.1.1.197
UniProtKB/Swiss-Prot
Q83E64, BIOC1_COXBU;  E3H9W1, BIOC1_ILYPC;  Q83CU8, BIOC2_COXBU;  
E3HCT1, BIOC2_ILYPC;  Q2KXN6, BIOCD_BORA1;  A3DBD7, BIOC_ACET2;  
Q6FDV0, BIOC_ACIAD;  Q0VMD3, BIOC_ALCBS;  B7GHW9, BIOC_ANOFW;  
Q81MB2, BIOC_BACAN;  A7GSD9, BIOC_BACCN;  Q818X2, BIOC_BACCR;  
E1WTS2, BIOC_BACF6;  Q64VX6, BIOC_BACFR;  E6SRF9, BIOC_BACT6;  
Q8A7S9, BIOC_BACTN;  C0Z787, BIOC_BREBN;  Q89AK7, BIOC_BUCBP;  
E4TI44, BIOC_CALNY;  Q3B172, BIOC_CHLL3;  A4SGV9, BIOC_CHLPM;  
Q47C02, BIOC_DECAR;  P12999, BIOC_ECOLI;  E3G327, BIOC_ENTLS;  
D8MPW4, BIOC_ERWBE;  D2T333, BIOC_ERWP6;  D9SJ16, BIOC_GALCS;  
Q749W5, BIOC_GEOSL;  Q7VL11, BIOC_HAEDU;  P45249, BIOC_HAEIN;  
Q2SBD7, BIOC_HAHCH;  Q9K623, BIOC_HALH5;  A1WVM4, BIOC_HALHL;  
C4K5L7, BIOC_HAMD5;  A4G5P1, BIOC_HERAR;  C1D5S5, BIOC_LARHH;  
Q5ZT34, BIOC_LEGPH;  A0L3L9, BIOC_MAGMM;  A6W0X8, BIOC_MARMS;  
Q609U9, BIOC_METCA;  E4QJB8, BIOC_METS6;  C6V598, BIOC_NEORI;  
Q2Y9Y6, BIOC_NITMU;  C6CWS7, BIOC_PAESJ;  Q6D3C1, BIOC_PECAS;  
Q7MUB2, BIOC_PORGI;  D5DIV9, BIOC_PRIM3;  B4S687, BIOC_PROA2;  
A6UYW3, BIOC_PSEA7;  O06898, BIOC_PSEVU;  Q8ZQQ6, BIOC_SALTY;  
P36571, BIOC_SERMA;  Q8EDK8, BIOC_SHEON;  B2IAI0, BIOC_XYLF2;  
Q7CH67, BIOC_YERPE;  B3PI89, BIOHC_CELJU;  Q21FY5, BIOHC_SACD2;  
C5BMZ8, BIOHC_TERTT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-