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ENZYME

ENZYME entry: EC 2.1.1.197

Accepted Name
malonyl-[acyl-carrier protein] O-methyltransferase
Reaction catalysed
malonyl-[ACP] + S-adenosyl-L-methionine <=> malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine
Comment(s)
  • Involved in an early step of biotin biosynthesis in Gram-negative bacteria.
  • This enzyme catalyzes the transfer of a methyl group to the omega- carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester.
  • The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl- [acyl-carrier-protein] methyl ester.
  • While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein].
Cross-references
BRENDA2.1.1.197
EC2PDB2.1.1.197
ExplorEnz2.1.1.197
PRIAM enzyme-specific profiles2.1.1.197
KEGG Ligand Database for Enzyme Nomenclature2.1.1.197
IUBMB Enzyme Nomenclature2.1.1.197
IntEnz2.1.1.197
MEDLINEFind literature relating to 2.1.1.197
MetaCyc2.1.1.197
Rhea expert-curated reactions2.1.1.197
UniProtKB/Swiss-Prot
Q83E64, BIOC1_COXBUE3H9W1, BIOC1_ILYPCQ83CU8, BIOC2_COXBU
E3HCT1, BIOC2_ILYPCQ2KXN6, BIOCD_BORA1A3DBD7, BIOC_ACET2
Q6FDV0, BIOC_ACIADQ0VMD3, BIOC_ALCBSB7GHW9, BIOC_ANOFW
Q81MB2, BIOC_BACANA7GSD9, BIOC_BACCNQ818X2, BIOC_BACCR
E1WTS2, BIOC_BACF6Q64VX6, BIOC_BACFRE6SRF9, BIOC_BACT6
Q8A7S9, BIOC_BACTNC0Z787, BIOC_BREBNQ89AK7, BIOC_BUCBP
E4TI44, BIOC_CALNYQ3B172, BIOC_CHLL3A4SGV9, BIOC_CHLPM
Q47C02, BIOC_DECARP12999, BIOC_ECOLIE3G327, BIOC_ENTLS
D8MPW4, BIOC_ERWBED2T333, BIOC_ERWP6D9SJ16, BIOC_GALCS
Q749W5, BIOC_GEOSLQ7VL11, BIOC_HAEDUP45249, BIOC_HAEIN
Q2SBD7, BIOC_HAHCHQ9K623, BIOC_HALH5A1WVM4, BIOC_HALHL
C4K5L7, BIOC_HAMD5A4G5P1, BIOC_HERARC1D5S5, BIOC_LARHH
Q5ZT34, BIOC_LEGPHA0L3L9, BIOC_MAGMMA6W0X8, BIOC_MARMS
Q609U9, BIOC_METCAE4QJB8, BIOC_METS6C6V598, BIOC_NEORI
Q2Y9Y6, BIOC_NITMUC6CWS7, BIOC_PAESJQ6D3C1, BIOC_PECAS
Q7MUB2, BIOC_PORGID5DIV9, BIOC_PRIM3B4S687, BIOC_PROA2
A6UYW3, BIOC_PSEA7O06898, BIOC_PSEVUQ8ZQQ6, BIOC_SALTY
P36571, BIOC_SERMAQ8EDK8, BIOC_SHEONB2IAI0, BIOC_XYLF2
Q7CH67, BIOC_YERPEB3PI89, BIOHC_CELJUQ21FY5, BIOHC_SACD2
C5BMZ8, BIOHC_TERTT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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