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ENZYME

ENZYME entry: EC 2.1.1.200

Accepted Name
tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase
Alternative Name(s)
TrMet(Xm32)
Reaction catalysed
  • cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
  • S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • In Escherichia coli TrmJ is the only methyltransferase responsible for the formation of 2'-O-methylcytidine(32) in tRNA.
  • No methylation of cytosine(34) in tRNA(Leu)(CAA).
  • In vitro the enzyme 2'-O-methylates cytidine(34) of tRNA(Ser1) and uridine(32) of tRNA(Gln2).
Cross-references
BRENDA2.1.1.200
EC2PDB2.1.1.200
ExplorEnz2.1.1.200
PRIAM enzyme-specific profiles2.1.1.200
KEGG Ligand Database for Enzyme Nomenclature2.1.1.200
IUBMB Enzyme Nomenclature2.1.1.200
IntEnz2.1.1.200
MEDLINEFind literature relating to 2.1.1.200
MetaCyc2.1.1.200
Rhea expert-curated reactions2.1.1.200
UniProtKB/Swiss-Prot
A8AD50, TRMJ_CITK8A7MGX5, TRMJ_CROS8Q8XA83, TRMJ_ECO57
A1AE69, TRMJ_ECOK1Q0TEV3, TRMJ_ECOL5P0AE02, TRMJ_ECOL6
P0AE01, TRMJ_ECOLIQ1R8K0, TRMJ_ECOUTA6TCF3, TRMJ_KLEP7
Q6D257, TRMJ_PECASQ7N222, TRMJ_PHOLLA0A0H2ZF87, TRMJ_PSEAB
Q57LG7, TRMJ_SALCHQ5PNG3, TRMJ_SALPAP66975, TRMJ_SALTI
P66974, TRMJ_SALTYQ31XV8, TRMJ_SHIBSQ32D32, TRMJ_SHIDS
Q0T1Y7, TRMJ_SHIF8P0AE03, TRMJ_SHIFLQ3YZ20, TRMJ_SHISS
Q2NS29, TRMJ_SODGMA1JKQ0, TRMJ_YERE8Q1C5G8, TRMJ_YERPA
Q7CJN8, TRMJ_YERPEQ1CKB1, TRMJ_YERPNA4TMV6, TRMJ_YERPP
Q667X9, TRMJ_YERPS

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