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ENZYME entry: EC 2.1.1.200
Accepted Name |
tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase.
|
Alternative Name(s) |
TrMet(Xm32). |
Reaction catalysed |
- cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
- S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine
|
Comment(s) |
- In Escherichia coli TrmJ is the only methyltransferase responsible
for the formation of 2'-O-methylcytidine(32) in tRNA.
- No methylation of cytosine(34) in tRNA(Leu)(CAA).
- In vitro the enzyme 2'-O-methylates cytidine(34) of tRNA(Ser1) and
uridine(32) of tRNA(Gln2).
|
Cross-references |
BRENDA | 2.1.1.200 |
EC2PDB | 2.1.1.200 |
ExplorEnz | 2.1.1.200 |
PRIAM enzyme-specific profiles | 2.1.1.200 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.200 |
IUBMB Enzyme Nomenclature | 2.1.1.200 |
IntEnz | 2.1.1.200 |
MEDLINE | Find literature relating to 2.1.1.200 |
MetaCyc | 2.1.1.200 |
Rhea expert-curated reactions | 2.1.1.200 |
UniProtKB/Swiss-Prot |
A8AD50, TRMJ_CITK8; | A7MGX5, TRMJ_CROS8; | Q8XA83, TRMJ_ECO57; |
A1AE69, TRMJ_ECOK1; | Q0TEV3, TRMJ_ECOL5; | P0AE02, TRMJ_ECOL6; |
P0AE01, TRMJ_ECOLI; | Q1R8K0, TRMJ_ECOUT; | A6TCF3, TRMJ_KLEP7; |
Q6D257, TRMJ_PECAS; | Q7N222, TRMJ_PHOLL; | A0A0H2ZF87, TRMJ_PSEAB; |
Q57LG7, TRMJ_SALCH; | Q5PNG3, TRMJ_SALPA; | P66975, TRMJ_SALTI; |
P66974, TRMJ_SALTY; | Q31XV8, TRMJ_SHIBS; | Q32D32, TRMJ_SHIDS; |
Q0T1Y7, TRMJ_SHIF8; | P0AE03, TRMJ_SHIFL; | Q3YZ20, TRMJ_SHISS; |
Q2NS29, TRMJ_SODGM; | A1JKQ0, TRMJ_YERE8; | Q1C5G8, TRMJ_YERPA; |
Q7CJN8, TRMJ_YERPE; | Q1CKB1, TRMJ_YERPN; | A4TMV6, TRMJ_YERPP; |
Q667X9, TRMJ_YERPS; |
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UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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