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ENZYME

ENZYME entry: EC 2.1.1.201

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.201
Accepted Name
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Alternative Name(s)
COQ5
Reaction catalysed
a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • This enzyme is involved in ubiquinone biosynthesis.
  • Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.
  • However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
  • For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant.
  • The bifunctional enzyme from E.coli also catalyzes the methylation of demethylmenaquinol-8 (this activity is classified as EC 2.1.1.163).
Cross-references
BRENDA2.1.1.201
EC2PDB2.1.1.201
ExplorEnz2.1.1.201
KEGG Ligand Database for Enzyme Nomenclature2.1.1.201
IUBMB Enzyme Nomenclature2.1.1.201
MEDLINEFind literature relating to 2.1.1.201
MetaCyc2.1.1.201
Rhea expert-curated reactions2.1.1.201
UniProtKB/Swiss-Prot
Q9LVC8, COQ5_ARATHQ0P5A2, COQ5_BOVINP34666, COQ5_CAEEL
Q5ZLL5, COQ5_CHICKQ66L51, COQ5_DANREQ54VN2, COQ5_DICDI
Q9VYF8, COQ5_DROMEQ5HYK3, COQ5_HUMANP55905, COQ5_LEIDO
Q9CXI0, COQ5_MOUSEQ5JNC0, COQ5_ORYSJQ5RBK6, COQ5_PONAB
Q4G064, COQ5_RATP87230, COQ5_SCHPOQ4V7R3, COQ5_XENLA
P49017, COQ5_YEASTA5FZ96, UBIE_ACICJQ8UIH5, UBIE_AGRFC
B9JZF4, UBIE_ALLAMC1DHS2, UBIE_AZOVDA1UUE1, UBIE_BARBK
Q6G577, UBIE_BARHEQ6G1I2, UBIE_BARQUA9ILA7, UBIE_BART1
Q6MHQ3, UBIE_BDEBAQ7VRJ1, UBIE_BLOFLQ491V7, UBIE_BLOPB
Q2KUG1, UBIE_BORA1Q7WF12, UBIE_BORBRQ7W3N6, UBIE_BORPA
Q7W0H1, UBIE_BORPEQ89WD0, UBIE_BRADUA5E888, UBIE_BRASB
A4YJH0, UBIE_BRASOB2SC50, UBIE_BRUA1Q2YJM4, UBIE_BRUA2
A6WYI0, UBIE_BRUA4Q576Q0, UBIE_BRUABA9MCZ2, UBIE_BRUC2
C0RMK3, UBIE_BRUMBQ8YDE4, UBIE_BRUMEA9WW74, UBIE_BRUSI
Q8FUZ3, UBIE_BRUSUB1YWF9, UBIE_BURA4A0KAF5, UBIE_BURCH
B4EBC4, UBIE_BURCJQ0BBY4, UBIE_BURCMQ39D13, UBIE_BURL3
A9AFC0, UBIE_BURM1A3MNT8, UBIE_BURM7A2S8L1, UBIE_BURM9
Q62MP4, UBIE_BURMAA1V753, UBIE_BURMSB1JYJ6, UBIE_BURO0
Q1BTN4, UBIE_BURO1A3NRJ4, UBIE_BURP0Q3JVZ6, UBIE_BURP1
A3N5U8, UBIE_BURP6Q63XA0, UBIE_BURPSQ2T139, UBIE_BURTA
A4JHS6, UBIE_BURVGA8FKB3, UBIE_CAMJ8Q9PIH5, UBIE_CAMJE
A1VY43, UBIE_CAMJJQ5HWE7, UBIE_CAMJRB0T7D0, UBIE_CAUSK
Q9A258, UBIE_CAUVCB8GVY5, UBIE_CAUVNB3PH48, UBIE_CELJU
A3PFL1, UBIE_CERS1Q3IY65, UBIE_CERS4A4WVR7, UBIE_CERS5
B9KQJ8, UBIE_CERSKQ7NZD3, UBIE_CHRVOB5EFL1, UBIE_CITBB
A8ACY2, UBIE_CITK8B6J676, UBIE_COXB1B6J3P6, UBIE_COXB2
A9KD75, UBIE_COXBNA9N9F4, UBIE_COXBRQ83A90, UBIE_COXBU
A7MQL7, UBIE_CROS8Q1LRG9, UBIE_CUPMCQ0KEH6, UBIE_CUPNH
Q475X0, UBIE_CUPPJB2AH07, UBIE_CUPTRQ6ANL3, UBIE_DESPS
A8LNK7, UBIE_DINSHA7ZU40, UBIE_ECO24B7UNG3, UBIE_ECO27
B7MHC0, UBIE_ECO45B7L996, UBIE_ECO55P0A888, UBIE_ECO57
B5YY82, UBIE_ECO5EB7NV33, UBIE_ECO7IB7N2E1, UBIE_ECO81
B7M638, UBIE_ECO8AC5A009, UBIE_ECOBWB1XAJ7, UBIE_ECODH
A8A6U0, UBIE_ECOHSA1AI22, UBIE_ECOK1Q0TAM1, UBIE_ECOL5
Q8FBJ0, UBIE_ECOL6B1IW72, UBIE_ECOLCP0A887, UBIE_ECOLI
B7NFD6, UBIE_ECOLUB6I4H5, UBIE_ECOSEB1LM21, UBIE_ECOSM
Q1R477, UBIE_ECOUTA4XPM7, UBIE_ECTM1Q9Z5E9, UBIE_ECTOL
C5BCA4, UBIE_EDWI9A4WFY5, UBIE_ENT38B2VG41, UBIE_ERWT9
B7LU01, UBIE_ESCF3B0TZP1, UBIE_FRAP2Q14GU4, UBIE_FRAT1
A7NAA1, UBIE_FRATFQ2A524, UBIE_FRATHB2SFA2, UBIE_FRATM
A0Q549, UBIE_FRATNQ0BNE2, UBIE_FRATOQ5NFE1, UBIE_FRATT
A4IXH9, UBIE_FRATWB9LZA9, UBIE_GEODFQ74EU2, UBIE_GEOSL
C6E4U6, UBIE_GEOSMA5GA37, UBIE_GEOURP59911, UBIE_HAEDU
Q2SN12, UBIE_HAHCHQ31IM5, UBIE_HYDCUQ5QYG2, UBIE_IDILO
B5XYI1, UBIE_KLEP3A6TGL3, UBIE_KLEP7C1DCV3, UBIE_LARHH
Q5X0X6, UBIE_LEGPAA5II90, UBIE_LEGPCQ5ZRH9, UBIE_LEGPH
Q5WSQ8, UBIE_LEGPLA6VTA1, UBIE_MARMSQ606J9, UBIE_METCA
B8IJ00, UBIE_METNOQ5F9R9, UBIE_NEIG1B4RK11, UBIE_NEIG2
A9M3A0, UBIE_NEIM0Q9JV83, UBIE_NEIMAQ9K075, UBIE_NEIMB
A1KT06, UBIE_NEIMFQ81ZZ8, UBIE_NITEUQ1QS47, UBIE_NITHX
Q2Y6R0, UBIE_NITMUA1BAN1, UBIE_PARDPB2JCU8, UBIE_PARP8
B2SX35, UBIE_PARPJQ145P0, UBIE_PARXLQ9CKD6, UBIE_PASMU
Q6DAQ7, UBIE_PECASC6DI77, UBIE_PECCPB4RC42, UBIE_PHEZH
Q7MZ81, UBIE_PHOLLB4EWC9, UBIE_PROMHQ48PJ4, UBIE_PSE14
B7V3F6, UBIE_PSEA8Q02EV4, UBIE_PSEABQ9HUC0, UBIE_PSEAE
Q1I3T0, UBIE_PSEE4C3K8U4, UBIE_PSEFSA5WA45, UBIE_PSEP1
A6VDI6, UBIE_PSEP7Q3KJC5, UBIE_PSEPFB0KM36, UBIE_PSEPG
Q88D17, UBIE_PSEPKQ9Z439, UBIE_PSEPUB1J2S8, UBIE_PSEPW
Q87UZ2, UBIE_PSESMQ3IJV7, UBIE_PSET1Q4ZZG3, UBIE_PSEU2
A1SRS4, UBIE_PSYINQ8Y278, UBIE_RALN1B2UFG8, UBIE_RALPJ
B3PZ92, UBIE_RHIE6Q2KDB0, UBIE_RHIECQ1MME0, UBIE_RHIJ3
Q98GV1, UBIE_RHILOB5ZYK8, UBIE_RHILWQ92SK7, UBIE_RHIME
B9J7S8, UBIE_RHIR8Q2J2H9, UBIE_RHOP2Q6NDM2, UBIE_RHOPA
Q13EN8, UBIE_RHOPSB3Q619, UBIE_RHOPTC3PLF4, UBIE_RICAE
A8GPI0, UBIE_RICAHA8GXR2, UBIE_RICB8Q1RJY5, UBIE_RICBR
A8EZP4, UBIE_RICCKQ92GT5, UBIE_RICCNQ4UMW4, UBIE_RICFE
A8F2G9, UBIE_RICM5Q9ZCP3, UBIE_RICPRC4K2K3, UBIE_RICPU
B0BUT9, UBIE_RICROA8GT99, UBIE_RICRSQ68W57, UBIE_RICTY
Q16DL1, UBIE_ROSDOQ9JPD1, UBIE_RUBGIQ1GC56, UBIE_RUEST
Q21H69, UBIE_SACD2B5EZU8, UBIE_SALA4A9MIY3, UBIE_SALAR
Q57HN8, UBIE_SALCHB5FNW6, UBIE_SALDCB5QW73, UBIE_SALEP
B5RFM8, UBIE_SALG2B4TBR3, UBIE_SALHSB4SZ73, UBIE_SALNS
Q5PKP4, UBIE_SALPAA9MY97, UBIE_SALPBC0Q3E1, UBIE_SALPC
B5BIX9, UBIE_SALPKB4TNX9, UBIE_SALSVP0A2K6, UBIE_SALTI
P0A2K5, UBIE_SALTYA8G8B8, UBIE_SERP5A1SAJ8, UBIE_SHEAM
B8E6B6, UBIE_SHEB2A3D9F2, UBIE_SHEB5A6WIE9, UBIE_SHEB8
A9KYL8, UBIE_SHEB9Q12S23, UBIE_SHEDOQ088H8, UBIE_SHEFN
B0TJ16, UBIE_SHEHHA3QIE1, UBIE_SHELPQ8E9R7, UBIE_SHEON
A8H966, UBIE_SHEPAA4Y2Q5, UBIE_SHEPCB8CI06, UBIE_SHEPW
A0L1M4, UBIE_SHESAA8G0S7, UBIE_SHESHQ0HEA1, UBIE_SHESM
Q0HZP7, UBIE_SHESRA1RP78, UBIE_SHESWB1KR07, UBIE_SHEWM
B2TVI4, UBIE_SHIB3Q31UF3, UBIE_SHIBSQ32A11, UBIE_SHIDS
Q0SZ25, UBIE_SHIF8P0A889, UBIE_SHIFLQ3YVD2, UBIE_SHISS
C3MCY6, UBIE_SINFNA6UFF7, UBIE_SINMWB4SJ34, UBIE_STRM5
B2FUU6, UBIE_STRMKA4VGE5, UBIE_STUS1Q3A209, UBIE_SYNC1
C5BRL2, UBIE_TERTTQ3SM81, UBIE_THIDAA7MTX1, UBIE_VIBC1
A5F4E5, UBIE_VIBC3Q9KVQ6, UBIE_VIBCHC3LPS5, UBIE_VIBCM
Q87TH4, UBIE_VIBPAQ8DDP9, UBIE_VIBVUQ7MQ33, UBIE_VIBVY
Q8D382, UBIE_WIGBRQ73HZ4, UBIE_WOLPMC0R2Q3, UBIE_WOLWR
Q8PPP2, UBIE_XANACQ8P558, UBIE_XANCPQ2NYW4, UBIE_XANOM
B2IA21, UBIE_XYLF2Q9PD92, UBIE_XYLFAB0U6V1, UBIE_XYLFM
Q87DI1, UBIE_XYLFTA1JIF2, UBIE_YERE8A7FDE0, UBIE_YERP3
Q1CBG0, UBIE_YERPAB2K0Y4, UBIE_YERPBQ8D1I3, UBIE_YERPE
A9R431, UBIE_YERPGQ1CNB4, UBIE_YERPNA4TR39, UBIE_YERPP
Q66FT0, UBIE_YERPSB1JP75, UBIE_YERPYQ9X3X2, UBIE_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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