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ENZYME

ENZYME entry: EC 2.1.1.201

Accepted Name
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Reaction catalysed
a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • This enzyme is involved in ubiquinone biosynthesis.
  • Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.
  • However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
  • For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant.
  • The bifunctional enzyme from E.coli also catalyzes the methylation of demethylmenaquinol-8 (this activity is classified as EC 2.1.1.163).
Cross-references
BRENDA2.1.1.201
EC2PDB2.1.1.201
ExplorEnz2.1.1.201
PRIAM enzyme-specific profiles2.1.1.201
KEGG Ligand Database for Enzyme Nomenclature2.1.1.201
IUBMB Enzyme Nomenclature2.1.1.201
IntEnz2.1.1.201
MEDLINEFind literature relating to 2.1.1.201
MetaCyc2.1.1.201
Rhea expert-curated reactions2.1.1.201
UniProtKB/Swiss-Prot
Q9LVC8, COQ5_ARATHQ0P5A2, COQ5_BOVINP34666, COQ5_CAEEL
Q5ZLL5, COQ5_CHICKQ66L51, COQ5_DANREQ54VN2, COQ5_DICDI
Q9VYF8, COQ5_DROMEQ5HYK3, COQ5_HUMANP55905, COQ5_LEIDO
Q9CXI0, COQ5_MOUSEQ5JNC0, COQ5_ORYSJQ5RBK6, COQ5_PONAB
Q4G064, COQ5_RATP87230, COQ5_SCHPOQ4V7R3, COQ5_XENLA
P49017, COQ5_YEASTA5FZ96, UBIE_ACICJQ8UIH5, UBIE_AGRFC
B9J7S8, UBIE_AGRRKB9JZF4, UBIE_AGRVSC1DHS2, UBIE_AZOVD
A1UUE1, UBIE_BARBKQ6G577, UBIE_BARHEQ6G1I2, UBIE_BARQU
A9ILA7, UBIE_BART1Q6MHQ3, UBIE_BDEBAQ7VRJ1, UBIE_BLOFL
Q491V7, UBIE_BLOPBQ2KUG1, UBIE_BORA1Q7WF12, UBIE_BORBR
Q7W3N6, UBIE_BORPAQ7W0H1, UBIE_BORPEQ89WD0, UBIE_BRADU
A5E888, UBIE_BRASBA4YJH0, UBIE_BRASOB2SC50, UBIE_BRUA1
Q2YJM4, UBIE_BRUA2A6WYI0, UBIE_BRUA4Q576Q0, UBIE_BRUAB
A9MCZ2, UBIE_BRUC2C0RMK3, UBIE_BRUMBQ8YDE4, UBIE_BRUME
A9WW74, UBIE_BRUSIQ8FUZ3, UBIE_BRUSUB1YWF9, UBIE_BURA4
A0KAF5, UBIE_BURCHB4EBC4, UBIE_BURCJQ0BBY4, UBIE_BURCM
Q39D13, UBIE_BURL3A9AFC0, UBIE_BURM1A3MNT8, UBIE_BURM7
A2S8L1, UBIE_BURM9Q62MP4, UBIE_BURMAA1V753, UBIE_BURMS
B1JYJ6, UBIE_BURO0Q1BTN4, UBIE_BURO1A3NRJ4, UBIE_BURP0
Q3JVZ6, UBIE_BURP1A3N5U8, UBIE_BURP6Q63XA0, UBIE_BURPS
Q2T139, UBIE_BURTAA4JHS6, UBIE_BURVGA8FKB3, UBIE_CAMJ8
Q9PIH5, UBIE_CAMJEA1VY43, UBIE_CAMJJQ5HWE7, UBIE_CAMJR
B0T7D0, UBIE_CAUSKQ9A258, UBIE_CAUVCB8GVY5, UBIE_CAUVN
B3PH48, UBIE_CELJUA3PFL1, UBIE_CERS1Q3IY65, UBIE_CERS4
A4WVR7, UBIE_CERS5B9KQJ8, UBIE_CERSKQ7NZD3, UBIE_CHRVO
B5EFL1, UBIE_CITBBA8ACY2, UBIE_CITK8B6J676, UBIE_COXB1
B6J3P6, UBIE_COXB2A9KD75, UBIE_COXBNA9N9F4, UBIE_COXBR
Q83A90, UBIE_COXBUA7MQL7, UBIE_CROS8Q1LRG9, UBIE_CUPMC
Q0KEH6, UBIE_CUPNHQ475X0, UBIE_CUPPJB2AH07, UBIE_CUPTR
Q6ANL3, UBIE_DESPSA8LNK7, UBIE_DINSHA7ZU40, UBIE_ECO24
B7UNG3, UBIE_ECO27B7MHC0, UBIE_ECO45B7L996, UBIE_ECO55
P0A888, UBIE_ECO57B5YY82, UBIE_ECO5EB7NV33, UBIE_ECO7I
B7N2E1, UBIE_ECO81B7M638, UBIE_ECO8AC5A009, UBIE_ECOBW
B1XAJ7, UBIE_ECODHA8A6U0, UBIE_ECOHSA1AI22, UBIE_ECOK1
Q0TAM1, UBIE_ECOL5Q8FBJ0, UBIE_ECOL6B1IW72, UBIE_ECOLC
P0A887, UBIE_ECOLIB7NFD6, UBIE_ECOLUB6I4H5, UBIE_ECOSE
B1LM21, UBIE_ECOSMQ1R477, UBIE_ECOUTC5BCA4, UBIE_EDWI9
A4WFY5, UBIE_ENT38B2VG41, UBIE_ERWT9B7LU01, UBIE_ESCF3
B0TZP1, UBIE_FRAP2Q14GU4, UBIE_FRAT1A7NAA1, UBIE_FRATF
Q2A524, UBIE_FRATHB2SFA2, UBIE_FRATMA0Q549, UBIE_FRATN
Q0BNE2, UBIE_FRATOQ5NFE1, UBIE_FRATTA4IXH9, UBIE_FRATW
B9LZA9, UBIE_GEODFQ74EU2, UBIE_GEOSLC6E4U6, UBIE_GEOSM
A5GA37, UBIE_GEOURP59911, UBIE_HAEDUQ2SN12, UBIE_HAHCH
Q31IM5, UBIE_HYDCUQ5QYG2, UBIE_IDILOB5XYI1, UBIE_KLEP3
A6TGL3, UBIE_KLEP7C1DCV3, UBIE_LARHHQ5X0X6, UBIE_LEGPA
A5II90, UBIE_LEGPCQ5ZRH9, UBIE_LEGPHQ5WSQ8, UBIE_LEGPL
A6VTA1, UBIE_MARMSQ606J9, UBIE_METCAB8IJ00, UBIE_METNO
Q5F9R9, UBIE_NEIG1B4RK11, UBIE_NEIG2A9M3A0, UBIE_NEIM0
Q9JV83, UBIE_NEIMAQ9K075, UBIE_NEIMBA1KT06, UBIE_NEIMF
Q81ZZ8, UBIE_NITEUQ1QS47, UBIE_NITHXQ2Y6R0, UBIE_NITMU
A1BAN1, UBIE_PARDPB2JCU8, UBIE_PARP8B2SX35, UBIE_PARPJ
Q145P0, UBIE_PARXLQ9CKD6, UBIE_PASMUQ6DAQ7, UBIE_PECAS
C6DI77, UBIE_PECCPB4RC42, UBIE_PHEZHQ7MZ81, UBIE_PHOLL
B4EWC9, UBIE_PROMHQ48PJ4, UBIE_PSE14A6VDI6, UBIE_PSEA7
B7V3F6, UBIE_PSEA8Q02EV4, UBIE_PSEABQ9HUC0, UBIE_PSEAE
Q1I3T0, UBIE_PSEE4C3K8U4, UBIE_PSEFSA4XPM7, UBIE_PSEMY
Q9Z5E9, UBIE_PSEOLA5WA45, UBIE_PSEP1Q3KJC5, UBIE_PSEPF
B0KM36, UBIE_PSEPGQ88D17, UBIE_PSEPKQ9Z439, UBIE_PSEPU
B1J2S8, UBIE_PSEPWQ87UZ2, UBIE_PSESMQ3IJV7, UBIE_PSET1
Q4ZZG3, UBIE_PSEU2A4VGE5, UBIE_PSEU5A1SRS4, UBIE_PSYIN
B2UFG8, UBIE_RALPJQ8Y278, UBIE_RALSOB3PZ92, UBIE_RHIE6
Q2KDB0, UBIE_RHIECQ1MME0, UBIE_RHIL3Q98GV1, UBIE_RHILO
B5ZYK8, UBIE_RHILWQ92SK7, UBIE_RHIMEQ2J2H9, UBIE_RHOP2
Q6NDM2, UBIE_RHOPAQ13EN8, UBIE_RHOPSB3Q619, UBIE_RHOPT
C3PLF4, UBIE_RICAEA8GPI0, UBIE_RICAHA8GXR2, UBIE_RICB8
Q1RJY5, UBIE_RICBRA8EZP4, UBIE_RICCKQ92GT5, UBIE_RICCN
Q4UMW4, UBIE_RICFEA8F2G9, UBIE_RICM5Q9ZCP3, UBIE_RICPR
C4K2K3, UBIE_RICPUB0BUT9, UBIE_RICROA8GT99, UBIE_RICRS
Q68W57, UBIE_RICTYQ16DL1, UBIE_ROSDOQ9JPD1, UBIE_RUBGI
Q1GC56, UBIE_RUESTQ21H69, UBIE_SACD2B5EZU8, UBIE_SALA4
A9MIY3, UBIE_SALARQ57HN8, UBIE_SALCHB5FNW6, UBIE_SALDC
B5QW73, UBIE_SALEPB5RFM8, UBIE_SALG2B4TBR3, UBIE_SALHS
B4SZ73, UBIE_SALNSQ5PKP4, UBIE_SALPAA9MY97, UBIE_SALPB
C0Q3E1, UBIE_SALPCB5BIX9, UBIE_SALPKB4TNX9, UBIE_SALSV
P0A2K6, UBIE_SALTIP0A2K5, UBIE_SALTYA8G8B8, UBIE_SERP5
A1SAJ8, UBIE_SHEAMB8E6B6, UBIE_SHEB2A3D9F2, UBIE_SHEB5
A6WIE9, UBIE_SHEB8A9KYL8, UBIE_SHEB9Q12S23, UBIE_SHEDO
Q088H8, UBIE_SHEFNB0TJ16, UBIE_SHEHHA3QIE1, UBIE_SHELP
Q8E9R7, UBIE_SHEONA8H966, UBIE_SHEPAA4Y2Q5, UBIE_SHEPC
B8CI06, UBIE_SHEPWA0L1M4, UBIE_SHESAA8G0S7, UBIE_SHESH
Q0HEA1, UBIE_SHESMQ0HZP7, UBIE_SHESRA1RP78, UBIE_SHESW
B1KR07, UBIE_SHEWMB2TVI4, UBIE_SHIB3Q31UF3, UBIE_SHIBS
Q32A11, UBIE_SHIDSQ0SZ25, UBIE_SHIF8P0A889, UBIE_SHIFL
Q3YVD2, UBIE_SHISSC3MCY6, UBIE_SINFNA6UFF7, UBIE_SINMW
B4SJ34, UBIE_STRM5B2FUU6, UBIE_STRMKQ3A209, UBIE_SYNC1
C5BRL2, UBIE_TERTTQ3SM81, UBIE_THIDAA7MTX1, UBIE_VIBC1
A5F4E5, UBIE_VIBC3Q9KVQ6, UBIE_VIBCHC3LPS5, UBIE_VIBCM
Q87TH4, UBIE_VIBPAQ8DDP9, UBIE_VIBVUQ7MQ33, UBIE_VIBVY
Q8D382, UBIE_WIGBRQ73HZ4, UBIE_WOLPMC0R2Q3, UBIE_WOLWR
Q8PPP2, UBIE_XANACQ8P558, UBIE_XANCPQ2NYW4, UBIE_XANOM
B2IA21, UBIE_XYLF2Q9PD92, UBIE_XYLFAB0U6V1, UBIE_XYLFM
Q87DI1, UBIE_XYLFTA1JIF2, UBIE_YERE8A7FDE0, UBIE_YERP3
Q1CBG0, UBIE_YERPAB2K0Y4, UBIE_YERPBQ8D1I3, UBIE_YERPE
A9R431, UBIE_YERPGQ1CNB4, UBIE_YERPNA4TR39, UBIE_YERPP
Q66FT0, UBIE_YERPSB1JP75, UBIE_YERPYQ9X3X2, UBIE_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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