Expasy logo

ENZYME

ENZYME entry: EC 2.1.1.201

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.201
Accepted Name
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Alternative Name(s)
COQ5
Reaction catalysed
a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • This enzyme is involved in ubiquinone biosynthesis.
  • Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.
  • However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
  • For example, when the COQ5 gene from Saccharomyces cerevisiae is introduced into Escherichia coli, it complements the respiratory deficiency of an ubiE mutant.
  • The bifunctional enzyme from E.coli also catalyzes the methylation of demethylmenaquinol-8 (this activity is classified as EC 2.1.1.163).
Cross-references
Rhea expert-curated reactions2.1.1.201
ExplorEnz2.1.1.201
IUBMB Enzyme Nomenclature2.1.1.201
UniProtKB/Swiss-Prot
Q9LVC8, COQ5_ARATHQ0P5A2, COQ5_BOVINP34666, COQ5_CAEEL
Q5ZLL5, COQ5_CHICKQ66L51, COQ5_DANREQ54VN2, COQ5_DICDI
Q9VYF8, COQ5_DROMEQ5HYK3, COQ5_HUMANP55905, COQ5_LEIDO
Q9CXI0, COQ5_MOUSEQ5JNC0, COQ5_ORYSJQ5RBK6, COQ5_PONAB
Q4G064, COQ5_RATP87230, COQ5_SCHPOQ4V7R3, COQ5_XENLA
P49017, COQ5_YEASTA5FZ96, UBIE_ACICJQ8UIH5, UBIE_AGRFC
B9JZF4, UBIE_ALLAMC1DHS2, UBIE_AZOVDA1UUE1, UBIE_BARBK
Q6G577, UBIE_BARHEQ6G1I2, UBIE_BARQUA9ILA7, UBIE_BART1
Q6MHQ3, UBIE_BDEBAQ7VRJ1, UBIE_BLOFLQ491V7, UBIE_BLOPB
Q2KUG1, UBIE_BORA1Q7WF12, UBIE_BORBRQ7W3N6, UBIE_BORPA
Q7W0H1, UBIE_BORPEQ89WD0, UBIE_BRADUA5E888, UBIE_BRASB
A4YJH0, UBIE_BRASOB2SC50, UBIE_BRUA1Q2YJM4, UBIE_BRUA2
A6WYI0, UBIE_BRUA4Q576Q0, UBIE_BRUABA9MCZ2, UBIE_BRUC2
C0RMK3, UBIE_BRUMBQ8YDE4, UBIE_BRUMEA9WW74, UBIE_BRUSI
Q8FUZ3, UBIE_BRUSUB1YWF9, UBIE_BURA4A0KAF5, UBIE_BURCH
B4EBC4, UBIE_BURCJQ0BBY4, UBIE_BURCMQ39D13, UBIE_BURL3
A9AFC0, UBIE_BURM1A3MNT8, UBIE_BURM7A2S8L1, UBIE_BURM9
Q62MP4, UBIE_BURMAA1V753, UBIE_BURMSB1JYJ6, UBIE_BURO0
Q1BTN4, UBIE_BURO1A3NRJ4, UBIE_BURP0Q3JVZ6, UBIE_BURP1
A3N5U8, UBIE_BURP6Q63XA0, UBIE_BURPSQ2T139, UBIE_BURTA
A4JHS6, UBIE_BURVGA8FKB3, UBIE_CAMJ8Q9PIH5, UBIE_CAMJE
A1VY43, UBIE_CAMJJQ5HWE7, UBIE_CAMJRB0T7D0, UBIE_CAUSK
Q9A258, UBIE_CAUVCB8GVY5, UBIE_CAUVNB3PH48, UBIE_CELJU
A3PFL1, UBIE_CERS1Q3IY65, UBIE_CERS4A4WVR7, UBIE_CERS5
B9KQJ8, UBIE_CERSKQ7NZD3, UBIE_CHRVOB5EFL1, UBIE_CITBB
A8ACY2, UBIE_CITK8B6J676, UBIE_COXB1B6J3P6, UBIE_COXB2
A9KD75, UBIE_COXBNA9N9F4, UBIE_COXBRQ83A90, UBIE_COXBU
A7MQL7, UBIE_CROS8Q1LRG9, UBIE_CUPMCQ0KEH6, UBIE_CUPNH
Q475X0, UBIE_CUPPJB2AH07, UBIE_CUPTRQ6ANL3, UBIE_DESPS
A8LNK7, UBIE_DINSHA7ZU40, UBIE_ECO24B7UNG3, UBIE_ECO27
B7MHC0, UBIE_ECO45B7L996, UBIE_ECO55P0A888, UBIE_ECO57
B5YY82, UBIE_ECO5EB7NV33, UBIE_ECO7IB7N2E1, UBIE_ECO81
B7M638, UBIE_ECO8AC5A009, UBIE_ECOBWB1XAJ7, UBIE_ECODH
A8A6U0, UBIE_ECOHSA1AI22, UBIE_ECOK1Q0TAM1, UBIE_ECOL5
Q8FBJ0, UBIE_ECOL6B1IW72, UBIE_ECOLCP0A887, UBIE_ECOLI
B7NFD6, UBIE_ECOLUB6I4H5, UBIE_ECOSEB1LM21, UBIE_ECOSM
Q1R477, UBIE_ECOUTA4XPM7, UBIE_ECTM1Q9Z5E9, UBIE_ECTOL
C5BCA4, UBIE_EDWI9A4WFY5, UBIE_ENT38B2VG41, UBIE_ERWT9
B7LU01, UBIE_ESCF3B0TZP1, UBIE_FRAP2Q14GU4, UBIE_FRAT1
A7NAA1, UBIE_FRATFQ2A524, UBIE_FRATHB2SFA2, UBIE_FRATM
A0Q549, UBIE_FRATNQ0BNE2, UBIE_FRATOQ5NFE1, UBIE_FRATT
A4IXH9, UBIE_FRATWB9LZA9, UBIE_GEODFQ74EU2, UBIE_GEOSL
C6E4U6, UBIE_GEOSMA5GA37, UBIE_GEOURP59911, UBIE_HAEDU
Q2SN12, UBIE_HAHCHQ31IM5, UBIE_HYDCUQ5QYG2, UBIE_IDILO
A6TGL3, UBIE_KLEP7B5XYI1, UBIE_KLEV3C1DCV3, UBIE_LARHH
Q5X0X6, UBIE_LEGPAA5II90, UBIE_LEGPCQ5ZRH9, UBIE_LEGPH
Q5WSQ8, UBIE_LEGPLA6VTA1, UBIE_MARMSQ606J9, UBIE_METCA
B8IJ00, UBIE_METNOQ5F9R9, UBIE_NEIG1B4RK11, UBIE_NEIG2
A9M3A0, UBIE_NEIM0Q9JV83, UBIE_NEIMAQ9K075, UBIE_NEIMB
A1KT06, UBIE_NEIMFQ81ZZ8, UBIE_NITEUQ1QS47, UBIE_NITHX
Q2Y6R0, UBIE_NITMUA1BAN1, UBIE_PARDPB2JCU8, UBIE_PARP8
B2SX35, UBIE_PARPJQ145P0, UBIE_PARXLQ9CKD6, UBIE_PASMU
Q6DAQ7, UBIE_PECASC6DI77, UBIE_PECCPB4RC42, UBIE_PHEZH
Q7MZ81, UBIE_PHOLLB4EWC9, UBIE_PROMHQ48PJ4, UBIE_PSE14
B7V3F6, UBIE_PSEA8Q02EV4, UBIE_PSEABQ9HUC0, UBIE_PSEAE
Q1I3T0, UBIE_PSEE4C3K8U4, UBIE_PSEFSA5WA45, UBIE_PSEP1
A6VDI6, UBIE_PSEP7Q3KJC5, UBIE_PSEPFB0KM36, UBIE_PSEPG
Q88D17, UBIE_PSEPKQ9Z439, UBIE_PSEPUB1J2S8, UBIE_PSEPW
Q87UZ2, UBIE_PSESMQ3IJV7, UBIE_PSET1Q4ZZG3, UBIE_PSEU2
A1SRS4, UBIE_PSYINQ8Y278, UBIE_RALN1B2UFG8, UBIE_RALPJ
B3PZ92, UBIE_RHIE6Q2KDB0, UBIE_RHIECQ1MME0, UBIE_RHIJ3
Q98GV1, UBIE_RHILOB5ZYK8, UBIE_RHILWQ92SK7, UBIE_RHIME
B9J7S8, UBIE_RHIR8Q2J2H9, UBIE_RHOP2Q6NDM2, UBIE_RHOPA
Q13EN8, UBIE_RHOPSB3Q619, UBIE_RHOPTC3PLF4, UBIE_RICAE
A8GPI0, UBIE_RICAHA8GXR2, UBIE_RICB8Q1RJY5, UBIE_RICBR
A8EZP4, UBIE_RICCKQ92GT5, UBIE_RICCNQ4UMW4, UBIE_RICFE
A8F2G9, UBIE_RICM5Q9ZCP3, UBIE_RICPRC4K2K3, UBIE_RICPU
B0BUT9, UBIE_RICROA8GT99, UBIE_RICRSQ68W57, UBIE_RICTY
Q16DL1, UBIE_ROSDOQ9JPD1, UBIE_RUBGIQ1GC56, UBIE_RUEST
Q21H69, UBIE_SACD2B5EZU8, UBIE_SALA4A9MIY3, UBIE_SALAR
Q57HN8, UBIE_SALCHB5FNW6, UBIE_SALDCB5QW73, UBIE_SALEP
B5RFM8, UBIE_SALG2B4TBR3, UBIE_SALHSB4SZ73, UBIE_SALNS
Q5PKP4, UBIE_SALPAA9MY97, UBIE_SALPBC0Q3E1, UBIE_SALPC
B5BIX9, UBIE_SALPKB4TNX9, UBIE_SALSVP0A2K6, UBIE_SALTI
P0A2K5, UBIE_SALTYA8G8B8, UBIE_SERP5A1SAJ8, UBIE_SHEAM
B8E6B6, UBIE_SHEB2A3D9F2, UBIE_SHEB5A6WIE9, UBIE_SHEB8
A9KYL8, UBIE_SHEB9Q12S23, UBIE_SHEDOQ088H8, UBIE_SHEFN
B0TJ16, UBIE_SHEHHA3QIE1, UBIE_SHELPQ8E9R7, UBIE_SHEON
A8H966, UBIE_SHEPAA4Y2Q5, UBIE_SHEPCB8CI06, UBIE_SHEPW
A0L1M4, UBIE_SHESAA8G0S7, UBIE_SHESHQ0HEA1, UBIE_SHESM
Q0HZP7, UBIE_SHESRA1RP78, UBIE_SHESWB1KR07, UBIE_SHEWM
B2TVI4, UBIE_SHIB3Q31UF3, UBIE_SHIBSQ32A11, UBIE_SHIDS
Q0SZ25, UBIE_SHIF8P0A889, UBIE_SHIFLQ3YVD2, UBIE_SHISS
C3MCY6, UBIE_SINFNA6UFF7, UBIE_SINMWB4SJ34, UBIE_STRM5
B2FUU6, UBIE_STRMKA4VGE5, UBIE_STUS1Q3A209, UBIE_SYNC1
C5BRL2, UBIE_TERTTQ3SM81, UBIE_THIDAA7MTX1, UBIE_VIBC1
A5F4E5, UBIE_VIBC3Q9KVQ6, UBIE_VIBCHC3LPS5, UBIE_VIBCM
Q87TH4, UBIE_VIBPAQ8DDP9, UBIE_VIBVUQ7MQ33, UBIE_VIBVY
Q8D382, UBIE_WIGBRQ73HZ4, UBIE_WOLPMC0R2Q3, UBIE_WOLWR
Q8PPP2, UBIE_XANACQ8P558, UBIE_XANCPQ2NYW4, UBIE_XANOM
B2IA21, UBIE_XYLF2Q9PD92, UBIE_XYLFAB0U6V1, UBIE_XYLFM
Q87DI1, UBIE_XYLFTA1JIF2, UBIE_YERE8A7FDE0, UBIE_YERP3
Q1CBG0, UBIE_YERPAB2K0Y4, UBIE_YERPBQ8D1I3, UBIE_YERPE
A9R431, UBIE_YERPGQ1CNB4, UBIE_YERPNA4TR39, UBIE_YERPP
Q66FT0, UBIE_YERPSB1JP75, UBIE_YERPYQ9X3X2, UBIE_ZYMMO
BRENDA2.1.1.201
MetaCyc2.1.1.201
KEGG Ligand Database for Enzyme Nomenclature2.1.1.201
EC2PDB2.1.1.201
MEDLINEFind literature relating to 2.1.1.201

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-