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ENZYME entry: EC 2.1.1.203

Accepted Name
tRNA (cytosine(34)-C(5))-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + cytosine(34) in tRNA precursor <=> S-adenosyl-L-homocysteine + 5-methylcytosine(34) in tRNA precursor
Comment(s)
  • The human enzyme is specific for C(5)-methylation of cytosine(34) in tRNA precursors.
  • The intron in the human pre-tRNA(Leu)(CAA) is indispensable for the C(5)-methylation of cytosine in the first position of the anticodon.
  • It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors.
  • Formerly EC 2.1.1.29.
Cross-references
BRENDA2.1.1.203
EC2PDB2.1.1.203
ExplorEnz2.1.1.203
PRIAM enzyme-specific profiles2.1.1.203
KEGG Ligand Database for Enzyme Nomenclature2.1.1.203
IUBMB Enzyme Nomenclature2.1.1.203
IntEnz2.1.1.203
MEDLINEFind literature relating to 2.1.1.203
MetaCyc2.1.1.203
Rhea expert-curated reactions2.1.1.203
UniProtKB/Swiss-Prot
Q5ZLV4, NSUN2_CHICK;  Q9W4M9, NSUN2_DROME;  Q08J23, NSUN2_HUMAN;  
Q1HFZ0, NSUN2_MOUSE;  Q4V7N2, NSUN2_XENLA;  Q28E61, NSUN2_XENTR;  
Q9HGQ2, TRM4A_SCHPO;  

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