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ENZYME entry: EC 2.1.1.204

Accepted Name
tRNA (cytosine(38)-C(5))-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + cytosine(38) in tRNA <=> S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA
Comment(s)
  • The eukaryotic enzyme catalyzes methylation of cytosine(38) in the anti-codon loop of tRNA(Asp)(GTC), tRNA(Val)(AAC) and tRNA(Gly)(GCC).
  • Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease.
  • Formerly EC 2.1.1.29.
Cross-references
PROSITEPDOC00089
BRENDA2.1.1.204
EC2PDB2.1.1.204
ExplorEnz2.1.1.204
PRIAM enzyme-specific profiles2.1.1.204
KEGG Ligand Database for Enzyme Nomenclature2.1.1.204
IUBMB Enzyme Nomenclature2.1.1.204
IntEnz2.1.1.204
MEDLINEFind literature relating to 2.1.1.204
MetaCyc2.1.1.204
UniProtKB/Swiss-Prot
P40999, PMT1M_SCHPO;  F4JWT7, TRDMT_ARATH;  Q7YS61, TRDMT_BOVIN;  
O14717, TRDMT_HUMAN;  O55055, TRDMT_MOUSE;  Q4G073, TRDMT_RAT;  
A0A2H1VE33, TRDMT_SPOFR;  

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