ENZYME entry: EC 2.1.1.207
| Accepted Name |
|---|
| tRNA (cytidine(34)-2'-O)-methyltransferase.
|
| Alternative Name(s) |
|---|
| tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-
methyltransferase. |
| tRNA methyltransferase L. |
| Reaction catalysed |
|---|
- S-adenosyl-L-methionine + cytidine(34) in tRNA <=> S-adenosyl-L-homocysteine + 2'-O-methylcytidine(34) in tRNA
- S-adenosyl-L-methionine + 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) <=> S-adenosyl-L-homocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu)
|
| Comment(s) |
|---|
- The enzyme from Escherichia coli catalyzes the 2'-O-methylation of
cytidine or 5-carboxymethylaminomethyluridine at the wobble position
at nucleotide 34 in tRNA(Leu)CmAA and tRNA(Leu)cmnm(5)UmAA.
- The enzyme is selective for the two tRNA(Leu) isoacceptors and only
methylates these when they present the correct anticodon loop
sequence and modification pattern.
- Specifically, YibK requires a pyrimidine nucleoside at position 34,
it has a clear preference for an adenosine at position 35, and it
fails to methylate without prior addition of the N(6)-(isopentenyl)-
2-methylthioadenosine modification at position 37.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.207 |
| EC2PDB | 2.1.1.207 |
| ExplorEnz | 2.1.1.207 |
| PRIAM enzyme-specific profiles | 2.1.1.207 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.207 |
| IUBMB Enzyme Nomenclature | 2.1.1.207 |
| IntEnz | 2.1.1.207 |
| MEDLINE | Find literature relating to 2.1.1.207 |
| MetaCyc | 2.1.1.207 |
| UniProtKB/Swiss-Prot |
| A1WBM9, TRML_ACISJ; | A0KEQ6, TRML_AERHH; | O31590, TRML_BACSU; |
| B2IBT9, TRML_BEII9; | A0KAS4, TRML_BURCH; | Q0BBL1, TRML_BURCM; |
| A3NR15, TRML_BURP0; | P0AGJ8, TRML_ECOL6; | P0AGJ7, TRML_ECOLI; |
| P32813, TRML_GEOSE; | P44868, TRML_HAEIN; | Q042B4, TRML_LACGA; |
| A2RKW7, TRML_LACLM; | P69001, TRML_LISIN; | Q721N0, TRML_LISMF; |
| C6X9I5, TRML_METGS; | P47588, TRML_MYCGE; | P75257, TRML_MYCPN; |
| C7BSD3, TRML_PHOAA; | Q12E50, TRML_POLSJ; | Q21LN7, TRML_SACD2; |
| B8CHC9, TRML_SHEPW; | D7A3L6, TRML_STAND; | Q48V41, TRML_STRPM; |
| P74516, TRML_SYNY3; | Q74Y93, TRML_YERPE; |
|
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