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ENZYME

ENZYME entry: EC 2.1.1.219

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.219
Accepted Name
tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase
Reaction catalysed
adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)
Comment(s)
  • The enzyme catalyzes the formation of N(1)-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNA(Asp)).
  • Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs.
  • Formerly EC 2.1.1.36.
Cross-references
BRENDA2.1.1.219
EC2PDB2.1.1.219
ExplorEnz2.1.1.219
KEGG Ligand Database for Enzyme Nomenclature2.1.1.219
IUBMB Enzyme Nomenclature2.1.1.219
MEDLINEFind literature relating to 2.1.1.219
MetaCyc2.1.1.219
Rhea expert-curated reactions2.1.1.219
UniProtKB/Swiss-Prot
Q57598, TRMI_METJAQ9V1J7, TRMI_PYRAB

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-