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ENZYME entry: EC 2.1.1.219

Accepted Name
tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase.
Reaction catalysed
2 S-adenosyl-L-methionine + adenine(57)/adenine(58) in tRNA <=> 2 S-adenosyl-L-homocysteine + N(1)-methyladenine(57)/N(1)-methyladenine(58) in tRNA
Comment(s)
  • The enzyme catalyzes the formation of N(1)-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNA(Asp)).
  • Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs.
  • Formerly EC 2.1.1.36.
Cross-references
BRENDA2.1.1.219
EC2PDB2.1.1.219
ExplorEnz2.1.1.219
PRIAM enzyme-specific profiles2.1.1.219
KEGG Ligand Database for Enzyme Nomenclature2.1.1.219
IUBMB Enzyme Nomenclature2.1.1.219
IntEnz2.1.1.219
MEDLINEFind literature relating to 2.1.1.219
MetaCyc2.1.1.219
Rhea expert-curated reactions2.1.1.219
UniProtKB/Swiss-Prot
Q57598, TRMI_METJA;  Q9V1J7, TRMI_PYRAB;  

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