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ENZYME entry: EC 2.1.1.220

Accepted Name
tRNA (adenine(58)-N(1))-methyltransferase.
Alternative Name(s)
tRNA (m(1)A(58)) methyltransferase.
tRNA m(1)A(58) methyltransferase.
Reaction catalysed
adenosine(58) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme specifically methylates adenine(58) in tRNA.
  • The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast.
  • Formerly EC 2.1.1.36.
Cross-references
BRENDA2.1.1.220
EC2PDB2.1.1.220
ExplorEnz2.1.1.220
PRIAM enzyme-specific profiles2.1.1.220
KEGG Ligand Database for Enzyme Nomenclature2.1.1.220
IUBMB Enzyme Nomenclature2.1.1.220
IntEnz2.1.1.220
MEDLINEFind literature relating to 2.1.1.220
MetaCyc2.1.1.220
Rhea expert-curated reactions2.1.1.220
UniProtKB/Swiss-Prot
Q9BVS5, TR61B_HUMAN;  Q755M8, TRM61_ASHGO;  Q4WUT7, TRM61_ASPFU;  
Q2U3W4, TRM61_ASPOR;  A6H791, TRM61_BOVIN;  Q5A416, TRM61_CANAL;  
Q6FL77, TRM61_CANGA;  P0CS09, TRM61_CRYNB;  P0CS08, TRM61_CRYNJ;  
Q6BX32, TRM61_DEBHA;  Q86JJ0, TRM61_DICDI;  Q96FX7, TRM61_HUMAN;  
Q6CN53, TRM61_KLULA;  Q80XC2, TRM61_MOUSE;  Q6AY46, TRM61_RAT;  
O14307, TRM61_SCHPO;  Q6C0P9, TRM61_YARLI;  P46959, TRM61_YEAST;  
P9WFZ0, TRMI_MYCTO;  P9WFZ1, TRMI_MYCTU;  Q8GBB2, TRMI_THET2;  
Q5SKN4, TRMI_THET8;  

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