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ENZYME

ENZYME entry: EC 2.1.1.220

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.220
Accepted Name
tRNA (adenine(58)-N(1))-methyltransferase
Alternative Name(s)
tRNA (m(1)A(58)) methyltransferase
tRNA m(1)A(58) methyltransferase
Reaction catalysed
adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • The enzyme specifically methylates adenine(58) in tRNA.
  • The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast.
  • Formerly EC 2.1.1.36.
Cross-references
BRENDA2.1.1.220
EC2PDB2.1.1.220
ExplorEnz2.1.1.220
KEGG Ligand Database for Enzyme Nomenclature2.1.1.220
IUBMB Enzyme Nomenclature2.1.1.220
MEDLINEFind literature relating to 2.1.1.220
MetaCyc2.1.1.220
Rhea expert-curated reactions2.1.1.220
UniProtKB/Swiss-Prot
Q9BVS5, TR61B_HUMANQ4WUT7, TRM61_ASPFUQ2U3W4, TRM61_ASPOR
A6H791, TRM61_BOVINQ5A416, TRM61_CANALQ6FL77, TRM61_CANGA
P0CS08, TRM61_CRYD1P0CS09, TRM61_CRYD3Q6BX32, TRM61_DEBHA
Q86JJ0, TRM61_DICDIQ755M8, TRM61_EREGSQ96FX7, TRM61_HUMAN
Q6CN53, TRM61_KLULAQ80XC2, TRM61_MOUSEQ6AY46, TRM61_RAT
O14307, TRM61_SCHPOQ6C0P9, TRM61_YARLIP46959, TRM61_YEAST
P9WFZ0, TRMI_MYCTOP9WFZ1, TRMI_MYCTUQ8GBB2, TRMI_THET2
Q5SKN4, TRMI_THET8

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-