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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.1.1.220

Accepted Name
tRNA (adenine(58)-N(1))-methyltransferase.
Alternative Name(s)
tRNA (m(1)A(58)) methyltransferase.
tRNA m(1)A(58) methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + adenine(58) in tRNA <=> S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA
Comment(s)
  • The enzyme specifically methylates adenine(58) in tRNA.
  • The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast.
  • Formerly EC 2.1.1.36.
Cross-references
BRENDA2.1.1.220
EC2PDB2.1.1.220
ExplorEnz2.1.1.220
PRIAM enzyme-specific profiles2.1.1.220
KEGG Ligand Database for Enzyme Nomenclature2.1.1.220
IUBMB Enzyme Nomenclature2.1.1.220
IntEnz2.1.1.220
MEDLINEFind literature relating to 2.1.1.220
MetaCyc2.1.1.220
UniProtKB/Swiss-Prot
Q9BVS5, TR61B_HUMAN;  Q755M8, TRM61_ASHGO;  Q4WUT7, TRM61_ASPFU;  
Q2U3W4, TRM61_ASPOR;  A6H791, TRM61_BOVIN;  Q5A416, TRM61_CANAL;  
Q6FL77, TRM61_CANGA;  P0CS09, TRM61_CRYNB;  P0CS08, TRM61_CRYNJ;  
Q6BX32, TRM61_DEBHA;  Q86JJ0, TRM61_DICDI;  Q96FX7, TRM61_HUMAN;  
Q6CN53, TRM61_KLULA;  Q80XC2, TRM61_MOUSE;  Q6AY46, TRM61_RAT;  
O14307, TRM61_SCHPO;  Q6C0P9, TRM61_YARLI;  P46959, TRM61_YEAST;  
P9WFZ0, TRMI_MYCTO;  P9WFZ1, TRMI_MYCTU;  Q8GBB2, TRMI_THET2;  
Q5SKN4, TRMI_THET8;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-