A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.1.1.220
| Accepted Name |
|---|
| tRNA (adenine(58)-N(1))-methyltransferase.
|
| Alternative Name(s) |
|---|
| tRNA (m(1)A(58)) methyltransferase. |
| tRNA m(1)A(58) methyltransferase. |
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + adenine(58) in tRNA <=> S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA |
| Comment(s) |
|---|
- The enzyme specifically methylates adenine(58) in tRNA.
- The methylation of A(58) is critical for maintaining the stability of
initiator tRNA(Met) in yeast.
- Formerly EC 2.1.1.36.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.220 |
| EC2PDB | 2.1.1.220 |
| ExplorEnz | 2.1.1.220 |
| PRIAM enzyme-specific profiles | 2.1.1.220 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.220 |
| IUBMB Enzyme Nomenclature | 2.1.1.220 |
| IntEnz | 2.1.1.220 |
| MEDLINE | Find literature relating to 2.1.1.220 |
| MetaCyc | 2.1.1.220 |
| UniProtKB/Swiss-Prot |
| Q9BVS5, TR61B_HUMAN; | Q755M8, TRM61_ASHGO; | Q4WUT7, TRM61_ASPFU; |
| Q2U3W4, TRM61_ASPOR; | A6H791, TRM61_BOVIN; | Q5A416, TRM61_CANAL; |
| Q6FL77, TRM61_CANGA; | P0CS09, TRM61_CRYNB; | P0CS08, TRM61_CRYNJ; |
| Q6BX32, TRM61_DEBHA; | Q86JJ0, TRM61_DICDI; | Q96FX7, TRM61_HUMAN; |
| Q6CN53, TRM61_KLULA; | Q80XC2, TRM61_MOUSE; | Q6AY46, TRM61_RAT; |
| O14307, TRM61_SCHPO; | Q6C0P9, TRM61_YARLI; | P46959, TRM61_YEAST; |
| P9WFZ0, TRMI_MYCTO; | P9WFZ1, TRMI_MYCTU; | Q8GBB2, TRMI_THET2; |
| Q5SKN4, TRMI_THET8; |
|
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