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ENZYME

ENZYME entry: EC 2.1.1.243

Accepted Name
5-guanidino-2-oxopentanoate (3R)-methyltransferase
Alternative Name(s)
2-ketoarginine methyltransferase
Reaction catalysed
5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine = (3R)-5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme is involved in production of the rare amino acid (3R)-3- methyl-L-arginine.
  • The compound is used by the epiphytic bacterium Pseudomonas syringae pv. syringae as an antibiotic against the related pathogenic species Pseudomonas savastanoi pv. glycinea.
  • Other bacteria incorporate the compound into more complex compounds such as the peptidyl nucleoside antibiotic arginomycin.
Cross-references
BRENDA2.1.1.243
EC2PDB2.1.1.243
ExplorEnz2.1.1.243
PRIAM enzyme-specific profiles2.1.1.243
KEGG Ligand Database for Enzyme Nomenclature2.1.1.243
IUBMB Enzyme Nomenclature2.1.1.243
IntEnz2.1.1.243
MEDLINEFind literature relating to 2.1.1.243
MetaCyc2.1.1.243
Rhea expert-curated reactions2.1.1.243
UniProtKB/Swiss-Prot
M1T9N7, ARGN_STRELD5FKJ3, MRSA_PSESY

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