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ENZYME

ENZYME entry: EC 2.1.1.244

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.244
Accepted Name
protein N-terminal methyltransferase
Reaction catalysed
  • N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)
  • N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)
  • N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)
Comment(s)
  • This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved.
  • When the terminal amino acid is L-proline, the enzyme catalyzes two successive methylations of its alpha-amino group.
  • When the first amino acid is either L-alanine or L-serine, the enzyme catalyzes three successive methylations.
  • The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids.
  • Formerly EC 2.1.1.n5.
Cross-references
BRENDA2.1.1.244
EC2PDB2.1.1.244
ExplorEnz2.1.1.244
KEGG Ligand Database for Enzyme Nomenclature2.1.1.244
IUBMB Enzyme Nomenclature2.1.1.244
MEDLINEFind literature relating to 2.1.1.244
MetaCyc2.1.1.244
Rhea expert-curated reactions2.1.1.244
UniProtKB/Swiss-Prot
Q4KL94, NT1AA_XENLAQ4KLE6, NT1AB_XENLAD2H163, NTM1A_AILME
Q2T9N3, NTM1A_BOVINQ6NWX7, NTM1A_DANREQ9BV86, NTM1A_HUMAN
Q8R2U4, NTM1A_MOUSEQ5BJX0, NTM1A_RATB1H2P7, NTM1A_XENTR
Q5PP70, NTM1_ARATHA8WVR2, NTM1_CAEBRQ9N4D9, NTM1_CAEEL
Q55DH6, NTM1_DICDIQ6NN40, NTM1_DROMEA2XMJ1, NTM1_ORYSI
Q10CT5, NTM1_ORYSJO13748, NTM1_SCHPOP38340, NTM1_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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