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ENZYME

ENZYME entry: EC 2.1.1.254

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.254
Accepted Name
erythromycin 3''-O-methyltransferase
Reaction catalysed
  • erythromycin C + S-adenosyl-L-methionine = erythromycin A + S-adenosyl-L-homocysteine + H(+)
  • erythromycin D + S-adenosyl-L-methionine = erythromycin B + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C, forming the most active form of the antibiotic, erythromycin A.
  • It can also methylate the precursor erythromycin D, forming erythromycin B, which is then converted to erythromycin A by EC 1.14.13.154.
Cross-references
Rhea expert-curated reactions2.1.1.254
ExplorEnz2.1.1.254
IUBMB Enzyme Nomenclature2.1.1.254
UniProtKB/Swiss-Prot
A4F7P5, ERYG_SACEN
BRENDA2.1.1.254
MetaCyc2.1.1.254
KEGG Ligand Database for Enzyme Nomenclature2.1.1.254
EC2PDB2.1.1.254
MEDLINEFind literature relating to 2.1.1.254

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