ID 2.1.1.282 DE tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]- DE methyltransferase. AN tRNA-yW synthesizing enzyme-3. CA 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + CA S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in CA tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine. CC -!- The enzyme is involved in the biosynthesis of hypermodified tricyclic CC bases found at position 37 of certain tRNAs. CC -!- These modifications are important for translational reading-frame CC maintenance. CC -!- The enzyme is found in all eukaryotes and in some archaea, but not in CC bacteria. CC -!- The eukaryotic enzyme is involved in the biosynthesis of wybutosine. DR Q8W4K1, TYW23_ARATH; Q8H4D4, TYW23_ORYSJ; Q9V074, TYW31_PYRAB; DR Q8U1V7, TYW31_PYRFU; O58796, TYW31_PYRHO; Q5JFK6, TYW31_THEKO; DR Q9V1Y5, TYW32_PYRAB; Q8TZG0, TYW32_PYRFU; O59533, TYW32_PYRHO; DR Q5JES6, TYW32_THEKO; Q9YDV3, TYW3_AERPE ; O28220, TYW3_ARCFU ; DR Q5E9U4, TYW3_BOVIN ; Q6DHJ1, TYW3_DANRE ; Q6IPR3, TYW3_HUMAN ; DR Q58905, TYW3_METJA ; Q8BSA9, TYW3_MOUSE ; Q19QT9, TYW3_PIG ; DR Q5R5S9, TYW3_PONAB ; Q9UX16, TYW3_SACS2 ; Q9UTA5, TYW3_SCHPO ; DR C6A5A3, TYW3_THESM ; Q641F8, TYW3_XENLA ; P53177, TYW3_YEAST ; //