ID 2.1.1.290 DE tRNA(Phe) [7-(3-amino-3-carboxypropyl)wyosine(37)-O]-methyltransferase. AN tRNA-yW synthesizing enzyme-4. CA 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L- CA methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in CA tRNA(Phe) + S-adenosyl-L-homocysteine. CC -!- The enzyme is found only in eukaryotes, where it is involved in the CC biosynthesis of wybutosine, a hypermodified tricyclic base found at CC position 37 of certain tRNAs. CC -!- The modification is important for translational reading-frame CC maintenance. CC -!- In some species that produce hydroxywybutosine the enzyme uses CC 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) as CC substrate. CC -!- The enzyme also has the activity of EC 2.3.1.231. DR Q4WVD1, TYW4_ASPFU ; Q2U6D4, TYW4_ASPOR ; Q5A931, TYW4_CANAL ; DR Q6FXA5, TYW4_CANGA ; Q5BH52, TYW4_EMENI ; Q75AW4, TYW4_EREGS ; DR Q4IER0, TYW4_GIBZE ; O60294, TYW4_HUMAN ; Q8BYR1, TYW4_MOUSE ; DR Q9P3K9, TYW4_NEUCR ; Q5XIA3, TYW4_RAT ; O60157, TYW4_SCHPO ; DR Q6C3P4, TYW4_YARLI ; Q08282, TYW4_YEAST ; //