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ENZYME entry: EC 2.1.1.292

Accepted Name
Carminomycin 4-O-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + carminomycin <=> S-adenosyl-L-homocysteine + daunorubicin
Comment(s)
  • The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin.
  • In vitro the enzyme from Streptomyces sp. C5 also catalyzes the 4-O- methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy- 13-deoxycarminomycin.
Cross-references
BRENDA2.1.1.292
EC2PDB2.1.1.292
ExplorEnz2.1.1.292
PRIAM enzyme-specific profiles2.1.1.292
KEGG Ligand Database for Enzyme Nomenclature2.1.1.292
IUBMB Enzyme Nomenclature2.1.1.292
IntEnz2.1.1.292
MEDLINEFind literature relating to 2.1.1.292
MetaCyc2.1.1.292
Rhea expert-curated reactions2.1.1.292
UniProtKB/Swiss-Prot
Q06528, DNRK_STRPE;  Q55216, DNRK_STRS5;  

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