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ENZYME

ENZYME entry: EC 2.1.1.292

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.292
Accepted Name
carminomycin 4-O-methyltransferase
Reaction catalysed
carminomycin + S-adenosyl-L-methionine = daunorubicin + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin.
  • In vitro the enzyme from Streptomyces sp. C5 also catalyzes the 4-O- methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy- 13-deoxycarminomycin.
Cross-references
Rhea expert-curated reactions2.1.1.292
ExplorEnz2.1.1.292
IUBMB Enzyme Nomenclature2.1.1.292
UniProtKB/Swiss-Prot
Q06528, DNRK_STRPEQ55216, DNRK_STRS5
BRENDA2.1.1.292
MetaCyc2.1.1.292
KEGG Ligand Database for Enzyme Nomenclature2.1.1.292
EC2PDB2.1.1.292
MEDLINEFind literature relating to 2.1.1.292

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