ID 2.1.1.296 DE methyltransferase cap2. AN cap2-MTase. AN mRNA (nucleoside-2'-O)-methyltransferase. CA a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl- CA ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = CA a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl- CA ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl- CA L-homocysteine. CC -!- The enzyme, found in higher eukaryotes including insects and CC vertebrates, and their viruses, methylates the ribose of the CC nucleoside at the second transcribed position of mRNAs and snRNAs. CC -!- This methylation is known as cap2. CC -!- The human enzyme can also methylate mRNA molecules where the upstream CC ribonucleotide is not methylated (see EC 2.1.1.57), but with lower CC efficiency. DR Q7ZVS8, CMTR2_DANRE; Q9UAS6, CMTR2_DROME; Q8IYT2, CMTR2_HUMAN; DR Q8BWQ4, CMTR2_MOUSE; Q5RAY7, CMTR2_PONAB; //