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ENZYME entry: EC 2.1.1.297

Accepted Name
Peptide chain release factor N(5)-glutamine methyltransferase.
Alternative Name(s)
N(5)-glutamine MTase.
N(5)-glutamine S-adenosyl-L-methionine dependent methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine <=> S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine
Comment(s)
  • Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity.
  • Formerly EC 2.1.1.n16.
Cross-references
BRENDA2.1.1.297
EC2PDB2.1.1.297
ExplorEnz2.1.1.297
PRIAM enzyme-specific profiles2.1.1.297
KEGG Ligand Database for Enzyme Nomenclature2.1.1.297
IUBMB Enzyme Nomenclature2.1.1.297
IntEnz2.1.1.297
MEDLINEFind literature relating to 2.1.1.297
MetaCyc2.1.1.297
UniProtKB/Swiss-Prot
Q9Y5R4, HEMK1_HUMAN;  Q921L7, HEMK1_MOUSE;  O14028, MTQ1_SCHPO;  
P53944, MTQ1_YEAST;  Q9UT94, MTQ2_SCHPO;  Q03920, MTQ2_YEAST;  
A9CG70, PRMC_AGRFC;  Q5E6T2, PRMC_ALIF1;  O66506, PRMC_AQUAE;  
Q81JX2, PRMC_BACAN;  Q814U1, PRMC_BACCR;  P45873, PRMC_BACSU;  
Q8A1D7, PRMC_BACTN;  Q8G3P4, PRMC_BIFLO;  O51215, PRMC_BORBU;  
Q7W022, PRMC_BORPE;  Q89XT8, PRMC_BRADU;  P57269, PRMC_BUCAI;  
Q8K9W9, PRMC_BUCAP;  Q89AT0, PRMC_BUCBP;  Q63QE9, PRMC_BURPS;  
Q9A9T7, PRMC_CAUVC;  A9WBM9, PRMC_CHLAA;  B0B9D1, PRMC_CHLT2;  
Q8KCD5, PRMC_CHLTE;  O84027, PRMC_CHLTR;  Q97F67, PRMC_CLOAB;  
A5HY34, PRMC_CLOBH;  A4QDG2, PRMC_CORGB;  P0DJB1, PRMC_CORGL;  
Q83AD8, PRMC_COXBU;  Q9RXR2, PRMC_DEIRA;  Q727D9, PRMC_DESVH;  
B8E004, PRMC_DICTD;  P0ACC1, PRMC_ECOLI;  Q831F7, PRMC_ENTFA;  
A6H162, PRMC_FLAPJ;  Q5NIA7, PRMC_FRATT;  Q8R619, PRMC_FUSNN;  
Q748B2, PRMC_GEOSL;  Q7NJS7, PRMC_GLOVI;  P45253, PRMC_HAEIN;  
Q1II29, PRMC_KORVE;  Q9CHX0, PRMC_LACLA;  Q8F987, PRMC_LEPIN;  
Q8Y4A9, PRMC_LISMO;  Q6F0I4, PRMC_MESFL;  Q2RFW1, PRMC_MOOTA;  
P45832, PRMC_MYCLE;  Q6MU88, PRMC_MYCMS;  A0R213, PRMC_MYCS2;  
P9WHV2, PRMC_MYCTO;  P9WHV3, PRMC_MYCTU;  Q5F5B4, PRMC_NEIG1;  
Q9CN82, PRMC_PASMU;  Q7VDL7, PRMC_PROMA;  Q9HVC8, PRMC_PSEAE;  
Q98G94, PRMC_RHILO;  Q7ULT2, PRMC_RHOBA;  Q2RWE0, PRMC_RHORT;  
Q3J2B7, PRMC_RHOS4;  Q2S0V8, PRMC_SALRD;  P40816, PRMC_SALTY;  
Q8EAR4, PRMC_SHEON;  Q32GZ5, PRMC_SHIDS;  P0ACC2, PRMC_SHIFL;  
Q2FWE1, PRMC_STAA8;  Q9K4E3, PRMC_STRCO;  Q8DPZ3, PRMC_STRR6;  
P74003, PRMC_SYNY3;  Q8DHV7, PRMC_THEEB;  Q9WYV8, PRMC_THEMA;  
B5YIQ8, PRMC_THEYD;  Q9KQ26, PRMC_VIBCH;  Q8PC99, PRMC_XANCP;  
Q9PD67, PRMC_XYLFA;  Q87DF7, PRMC_XYLFT;  Q7CIA2, PRMC_YERPE;  
Q1RH40, RFTRM_RICBR;  Q92G13, RFTRM_RICCN;  Q4UJU4, RFTRM_RICFE;  
Q9ZCB3, RFTRM_RICPR;  Q68VR6, RFTRM_RICTY;  

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