ENZYME entry: EC 2.1.1.297

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.297

Accepted Name

peptide chain release factor N(5)-glutamine methyltransferase

Alternative Name(s)

N(5)-glutamine MTase

N(5)-glutamine S-adenosyl-L-methionine dependent methyltransferase

Reaction catalysed

L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)

Comment(s)

Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity.
Formerly EC 2.1.1.n16.

Cross-references

BRENDA

2.1.1.297

EC2PDB

2.1.1.297

ExplorEnz

2.1.1.297

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.297

IUBMB Enzyme Nomenclature

2.1.1.297

MEDLINE

Find literature relating to 2.1.1.297

MetaCyc

2.1.1.297

Rhea expert-curated reactions

2.1.1.297

UniProtKB/Swiss-Prot

Q9Y5R4, HEMK1_HUMAN	Q921L7, HEMK1_MOUSE	O14028, MTQ1_SCHPO
P53944, MTQ1_YEAST	O28490, MTQ2_ARCFU	D4GW96, MTQ2_HALVD
Q58338, MTQ2_METJA	Q9UT94, MTQ2_SCHPO	Q03920, MTQ2_YEAST
A9CG70, PRMC_AGRFC	Q5E6T2, PRMC_ALIF1	O66506, PRMC_AQUAE
Q81JX2, PRMC_BACAN	Q814U1, PRMC_BACCR	P45873, PRMC_BACSU
Q8A1D7, PRMC_BACTN	Q8G3P4, PRMC_BIFLO	O51215, PRMC_BORBU
Q7W022, PRMC_BORPE	Q89XT8, PRMC_BRADU	P57269, PRMC_BUCAI
Q8K9W9, PRMC_BUCAP	Q89AT0, PRMC_BUCBP	Q63QE9, PRMC_BURPS
Q9A9T7, PRMC_CAUVC	Q3J2B7, PRMC_CERS4	A9WBM9, PRMC_CHLAA
B0B9D1, PRMC_CHLT2	Q8KCD5, PRMC_CHLTE	O84027, PRMC_CHLTR
Q97F67, PRMC_CLOAB	A5HY34, PRMC_CLOBH	A4QDG2, PRMC_CORGB
P0DJB1, PRMC_CORGL	Q83AD8, PRMC_COXBU	Q9RXR2, PRMC_DEIRA
B8E004, PRMC_DICTD	P0ACC1, PRMC_ECOLI	Q831F7, PRMC_ENTFA
A6H162, PRMC_FLAPJ	Q5NIA7, PRMC_FRATT	Q8R619, PRMC_FUSNN
Q748B2, PRMC_GEOSL	Q7NJS7, PRMC_GLOVI	P45253, PRMC_HAEIN
Q1II29, PRMC_KORVE	Q9CHX0, PRMC_LACLA	Q8F987, PRMC_LEPIN
Q8Y4A9, PRMC_LISMO	Q6F0I4, PRMC_MESFL	Q2RFW1, PRMC_MOOTA
P45832, PRMC_MYCLE	Q6MU88, PRMC_MYCMS	A0R213, PRMC_MYCS2
P9WHV2, PRMC_MYCTO	P9WHV3, PRMC_MYCTU	Q5F5B4, PRMC_NEIG1
Q727D9, PRMC_NITV2	Q9CN82, PRMC_PASMU	Q7VDL7, PRMC_PROMA
Q9HVC8, PRMC_PSEAE	Q98G94, PRMC_RHILO	Q7ULT2, PRMC_RHOBA
Q2RWE0, PRMC_RHORT	Q2S0V8, PRMC_SALRD	P40816, PRMC_SALTY
Q8EAR4, PRMC_SHEON	Q32GZ5, PRMC_SHIDS	P0ACC2, PRMC_SHIFL
Q2FWE1, PRMC_STAA8	Q9K4E3, PRMC_STRCO	Q8DPZ3, PRMC_STRR6
P74003, PRMC_SYNY3	Q9WYV8, PRMC_THEMA	Q8DHV7, PRMC_THEVB
B5YIQ8, PRMC_THEYD	Q9KQ26, PRMC_VIBCH	Q8PC99, PRMC_XANCP
Q9PD67, PRMC_XYLFA	Q87DF7, PRMC_XYLFT	Q7CIA2, PRMC_YERPE
Q1RH40, RFTRM_RICBR	Q92G13, RFTRM_RICCN	Q4UJU4, RFTRM_RICFE
Q9ZCB3, RFTRM_RICPR	Q68VR6, RFTRM_RICTY

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