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ENZYME entry: EC 2.1.1.301

Accepted Name
Cypemycin N-terminal methyltransferase.
Reaction catalysed
2 S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] <=> 2 S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
Comment(s)
  • The enzyme, isolated from Streptomyces sp. OH-4156, can methylate a variety of oligopeptides, cyclic peptides such as nisin and haloduracin, and the epsilon-amino group of lysine.
  • Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.
  • Formerly EC 2.1.1.n13.
Cross-references
BRENDA2.1.1.301
EC2PDB2.1.1.301
ExplorEnz2.1.1.301
PRIAM enzyme-specific profiles2.1.1.301
KEGG Ligand Database for Enzyme Nomenclature2.1.1.301
IUBMB Enzyme Nomenclature2.1.1.301
IntEnz2.1.1.301
MEDLINEFind literature relating to 2.1.1.301
MetaCyc2.1.1.301
Rhea expert-curated reactions2.1.1.301
UniProtKB/Swiss-Prot
E5KIC0, CYPM_STRSQ

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