ID   2.1.1.314
DE   diphthine methyl ester synthase.
AN   diphthine methyltransferase.
CA   2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor
CA   2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation
CA   elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine.
CC   -!- This eukaryotic enzyme is part of the biosynthetic pathway of
CC       diphthamide.
CC   -!- Different from the archaeal enzyme, which performs only 3
CC       methylations, producing diphthine (cf. EC 2.1.1.98).
CC   -!- The relevant histidine of elongation factor 2 is His(715) in mammals
CC       and His(699) in yeast.
DR   Q59NX9, DPH51_CANAL;  P0CU37, DPH52_CANAL;  O81769, DPH5_ARATH ;
DR   Q6MY91, DPH5_ASPFU ;  Q5E982, DPH5_BOVIN ;  Q6FXK9, DPH5_CANGA ;
DR   Q6BN80, DPH5_DEBHA ;  Q75JG8, DPH5_DICDI ;  Q5BFG0, DPH5_EMENI ;
DR   Q754E7, DPH5_EREGS ;  Q4HZI0, DPH5_GIBZE ;  Q9H2P9, DPH5_HUMAN ;
DR   Q6CIZ1, DPH5_KLULA ;  Q9CWQ0, DPH5_MOUSE ;  Q7S949, DPH5_NEUCR ;
DR   O74898, DPH5_SCHPO ;  Q6C1E0, DPH5_YARLI ;  P32469, DPH5_YEAST ;
//