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ENZYME entry: EC 2.1.1.337

Accepted Name
reticuline N-methyltransferase.
Reaction catalysed
  • (S)-reticuline + S-adenosyl-L-methionine <=> (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine
  • (S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine
Comment(s)
  • The enzyme from opium poppy (Papaver somniferum) can also methylate (R)-reticuline, tetrahydropapaverine, (S)-glaucine and (S)- bulbocapnine.
  • It is involved in the biosynthesis of the quaternary benzylisoquinoline alkaloid magnoflorine.
Cross-references
BRENDA2.1.1.337
EC2PDB2.1.1.337
ExplorEnz2.1.1.337
PRIAM enzyme-specific profiles2.1.1.337
KEGG Ligand Database for Enzyme Nomenclature2.1.1.337
IUBMB Enzyme Nomenclature2.1.1.337
IntEnz2.1.1.337
MEDLINEFind literature relating to 2.1.1.337
MetaCyc2.1.1.337
Rhea expert-curated reactions2.1.1.337
UniProtKB/Swiss-Prot
A0A1C9U5X5, RNMT_PAPSO

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