ID   2.1.1.342
DE   anaerobilin synthase.
CA   heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine =
CA   5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized
CA   [flavodoxin] + S-adenosyl-L-homocysteine.
CC   -!- The enzyme, studied from the bacterium Escherichia coli O157:H7, is a
CC       radical SAM (AdoMet) enzyme that is involved in heme degradation and
CC       iron utilization under anaerobic conditions.
CC   -!- The enzyme uses two SAM molecules for the reaction.
CC   -!- The first molecule is used to generate a 5'-deoxyadenosyl radical,
CC       which abstracts a hydrogen atom from the methyl group of the second
CC       SAM molecule.
CC   -!- The newly formed methylene radical attacks the substrate, causing a
CC       rearrangement of the porphyrin ring that results in the liberation of
CC       iron.
DR   A0A384LP51, CHUW_ECO57 ;
//