ID   2.1.1.354
DE   [histone H3]-lysine(4) N-trimethyltransferase.
CA   L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CA   N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-
CA   homocysteine.
CC   -!- This entry describes several enzymes that successively methylate the
CC       L-lysine(4) residue of histone H3 (H3K4), ultimately generating a
CC       trimethylated form.
CC   -!- These modifications influence the binding of chromatin-associated
CC       proteins.
CC   -!- In most cases the trimethylation of this position is associated with
CC       gene activation.
CC   -!- EC 2.1.1.364 describes enzymes that can catalyze only monomethylation
CC       of this substrate (the first sub-reaction of this entry).
CC   -!- Formerly EC 2.1.1.43.
DR   Q9VW15, ASH1_DROME ;  Q84WW6, ASHH1_ARATH;  Q9C5X4, ATX1_ARATH ;
DR   O23372, ATXR3_ARATH;  F4K1J4, ATXR7_ARATH;  Q6P2A1, PRDM9_DANRE;
DR   Q9NQV7, PRDM9_HUMAN;  Q96EQ9, PRDM9_MOUSE;  P0C6Y7, PRDM9_RAT  ;
DR   Q1LY77, SE1BA_DANRE;  Q5F3P8, SET1B_CHICK;  Q66J90, SET1B_XENLA;
DR   Q08D57, SET1B_XENTR;  Q4WNH8, SET1_ASPFU ;  Q2UMH3, SET1_ASPOR ;
DR   Q18221, SET1_CAEEL ;  Q5ABG1, SET1_CANAL ;  Q6FKB1, SET1_CANGA ;
DR   Q2GWF3, SET1_CHAGB ;  Q1DR06, SET1_COCIM ;  P0CO27, SET1_CRYNB ;
DR   P0CO26, SET1_CRYNJ ;  Q6BKL7, SET1_DEBHA ;  Q54HS3, SET1_DICDI ;
DR   Q5LJZ2, SET1_DROME ;  Q5B0Y5, SET1_EMENI ;  Q75D88, SET1_EREGS ;
DR   Q4I5R3, SET1_GIBZE ;  Q6CIT4, SET1_KLULA ;  Q8X0S9, SET1_NEUCR ;
DR   Q9Y7R4, SET1_SCHPO ;  Q4PB36, SET1_USTMA ;  Q6CEK8, SET1_YARLI ;
DR   P38827, SET1_YEAST ;  Q5BJI7, SMY2A_DANRE;  Q7ZXV5, SMY2A_XENLA;
DR   Q5RGL7, SMY2B_DANRE;  Q6GN68, SMY2B_XENLA;  Q8NB12, SMYD1_HUMAN;
DR   P97443, SMYD1_MOUSE;  Q0P585, SMYD2_BOVIN;  E1C5V0, SMYD2_CHICK;
DR   Q9NRG4, SMYD2_HUMAN;  Q8R5A0, SMYD2_MOUSE;  C3RZA1, SMYD2_PIG  ;
DR   Q7M6Z3, SMYD2_RAT  ;  Q9H7B4, SMYD3_HUMAN;  Q9CWR2, SMYD3_MOUSE;
DR   Q1L8U8, STB1A_DANRE;  Q08BR4, STB1B_DANRE;  Q8IRW8, TRR_DROME  ;
//