ID   2.1.1.356
DE   [histone H3]-lysine(27) N-trimethyltransferase.
CA   L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CA   N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CA   homocysteine.
CC   -!- This entry describes enzymes that successively methylate the
CC       L-lysine(27) residue of histone H3 (H3K27), ultimately generating a
CC       trimethylated form.
CC   -!- These modifications influence the binding of chromatin-associated
CC       proteins.
CC   -!- The methylation of lysine(27) leads to transcriptional repression of
CC       the affected target genes.
CC   -!- The enzyme associates with other proteins to form a complex that is
CC       essential for activity.
CC   -!- The enzyme can also methylate some non-histone proteins. cf.
CC       EC 2.1.1.369 and EC 2.1.1.371.
DR   Q5VN06, CLF_ORYSJ  ;  Q8S4P6, EZ1_MAIZE  ;  Q84UI6, EZ1_ORYSI  ;
DR   Q10MI4, EZ1_ORYSJ  ;  Q8S4P5, EZ2_MAIZE  ;  Q8S4P4, EZ3_MAIZE  ;
DR   Q9ZSM8, EZA1_ARATH ;  A7E2Z2, EZH1_BOVIN ;  Q92800, EZH1_HUMAN ;
DR   P70351, EZH1_MOUSE ;  Q5RDS6, EZH1_PONAB ;  Q98SM3, EZH2A_XENLA;
DR   Q4V863, EZH2B_XENLA;  Q08BS4, EZH2_DANRE ;  Q15910, EZH2_HUMAN ;
DR   Q4R381, EZH2_MACFA ;  Q61188, EZH2_MOUSE ;  Q28D84, EZH2_XENTR ;
DR   P42124, EZ_DROME   ;  O65312, MEDEA_ARATH;  O17514, MES2_CAEEL ;
//