ID   2.1.1.357
DE   [histone H3]-lysine(36) N-dimethyltransferase.
CA   L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) +
CA   N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-
CA   homocysteine.
CC   -!- This entry describes a group of metazoan enzymes that catalyze two
CC       successive methylations of lysine(36) of histone H3 (H3K36), forming
CC       mono- and dimethylated forms.
CC   -!- These modifications influence the binding of chromatin-associated
CC       proteins.
CC   -!- The product can be further methylated to the trimethyl form by
CC       EC 2.1.1.358.
CC   -!- The yeast SET2 enzyme can catalyze all three methylations (see
CC       EC 2.1.1.359).
DR   F4K1J4, ATXR7_ARATH;  Q9NH52, MES4_CAEEL ;  Q96L73, NSD1_HUMAN ;
DR   O88491, NSD1_MOUSE ;  O96028, NSD2_HUMAN ;  Q8BVE8, NSD2_MOUSE ;
DR   Q8MT36, NSD_DROME  ;  Q0VD24, SETMR_BOVIN;  Q53H47, SETMR_HUMAN;
DR   Q80UJ9, SETMR_MOUSE;  Q5I0M0, SETMR_RAT  ;  Q8I4F7, SMYDL_CAEEL;
//