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ENZYME entry: EC 2.1.1.358

Accepted Name
[Histone H3]-dimethyl-L-lysine(36) N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a [histone H3]-N(6),N(6)-dimethyl-L-lysine(36) <=> S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(36)
Comment(s)
  • The enzyme, found in metazoa, methylates a dimethylated L-lysine(36) residue of histone H3 (H3K36), which has been methylated previously by EC 2.1.1.357.
  • The homologous enzyme from yeast catalyzes all three methylations (see EC 2.1.1.359).
  • Formerly EC 2.1.1.34.
Cross-references
BRENDA2.1.1.358
EC2PDB2.1.1.358
ExplorEnz2.1.1.358
PRIAM enzyme-specific profiles2.1.1.358
KEGG Ligand Database for Enzyme Nomenclature2.1.1.358
IUBMB Enzyme Nomenclature2.1.1.358
IntEnz2.1.1.358
MEDLINEFind literature relating to 2.1.1.358
MetaCyc2.1.1.358

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