ID   2.1.1.359
DE   [histone H3]-lysine(36) N-trimethyltransferase.
CA   L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CA   N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-
CA   homocysteine.
CC   -!- The enzyme, characterized from yeast, catalyzes the successive
CC       methylation of lysine(36) of histone H3 (H3K36), forming the
CC       trimethylated form.
CC   -!- These modifications influence the binding of chromatin-associated
CC       proteins.
CC   -!- The enzyme couples the methylation reactions with transcriptional
CC       elongation through an interaction with the large subunit of RNA
CC       polymerase II.
CC   -!- In mammals this activity is catalyzed by two different enzymes,
CC       EC 2.1.1.357 and EC 2.1.1.358.
DR   Q9NR48, ASH1L_HUMAN;  Q99MY8, ASH1L_MOUSE;  Q6P2A1, PRDM9_DANRE;
DR   Q9NQV7, PRDM9_HUMAN;  Q96EQ9, PRDM9_MOUSE;  P0C6Y7, PRDM9_RAT  ;
DR   Q4WTT2, SET2_ASPFU ;  Q2UTN6, SET2_ASPOR ;  Q59XV0, SET2_CANAL ;
DR   Q6FX50, SET2_CANGA ;  Q2H988, SET2_CHAGB ;  Q1DU03, SET2_COCIM ;
DR   P0CO29, SET2_CRYNB ;  P0CO28, SET2_CRYNJ ;  Q6BM04, SET2_DEBHA ;
DR   Q5ASA5, SET2_EMENI ;  Q757Y8, SET2_EREGS ;  Q4IB50, SET2_GIBZE ;
DR   Q6CXP5, SET2_KLULA ;  Q7RZU4, SET2_NEUCR ;  O14026, SET2_SCHPO ;
DR   Q4PBL3, SET2_USTMA ;  Q6C5G5, SET2_YARLI ;  P46995, SET2_YEAST ;
DR   Q9BYW2, SETD2_HUMAN;  E9Q5F9, SETD2_MOUSE;  Q9C0A6, SETD5_HUMAN;
DR   Q5XJV7, SETD5_MOUSE;  Q8IE95, SETVS_PLAF7;
//