ID   2.1.1.360
DE   [histone H3]-lysine(79) N-trimethyltransferase.
CA   L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-
CA   trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine +
CA   3 H(+).
CC   -!- The enzyme successively methylates the L-lysine(79) residue of
CC       histone H3 (H3K79), ultimately generating a trimethylated form.
CC   -!- These modifications influence the binding of chromatin-associated
CC       proteins.
CC   -!- This is the only known methylation event of a lysine residue within
CC       the core region of a histone, as all other such modifications occur
CC       at the tail.
DR   Q6AW06, DOT11_CAEEL;  Q4GZF2, DOT1B_TRYB2;  Q4D9P2, DOT1B_TRYCC;
DR   Q55AX2, DOT1L_DICDI;  Q8INR6, DOT1L_DROME;  Q8TEK3, DOT1L_HUMAN;
DR   Q4WVH4, DOT1_ASPFU ;  Q2U696, DOT1_ASPOR ;  Q5A309, DOT1_CANAL ;
DR   Q6FNM5, DOT1_CANGA ;  Q2H9L1, DOT1_CHAGB ;  Q1DKD8, DOT1_COCIM ;
DR   P0CN14, DOT1_CRYD1 ;  P0CN15, DOT1_CRYD3 ;  Q6BTC8, DOT1_DEBHA ;
DR   Q5BH89, DOT1_EMENI ;  Q756E1, DOT1_EREGS ;  Q4IJP1, DOT1_GIBZE ;
DR   Q6CWV1, DOT1_KLULA ;  Q4P2W8, DOT1_MYCMD ;  Q7SB74, DOT1_NEUCR ;
DR   Q6C4Y5, DOT1_YARLI ;  Q04089, DOT1_YEAST ;  A0A140C435, SETD4_ARTPA;
DR   P9WLL9, Y2067_MYCTU;
//