ID   2.1.1.361
DE   [histone H4]-lysine(20) N-methyltransferase.
CA   L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-
CA   L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine.
CC   -!- The enzyme catalyzes the monomethylation of the L-lysine(20) residue
CC       of histone H4 (H4K20).
CC   -!- This event is usually followed by further methylation by
CC       EC 2.1.1.362, [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
CC   -!- This enzyme plays a pivotal role in DNA replication.
CC   -!- Activity is high during the G2 and M phases, but declines
CC       significantly during G1 and S phases.
CC   -!- Mutations in the enzyme have severe consequences, including DNA
CC       double-strand breaks, activation of DNA damage checkpoints, defective
CC       cell cycle progression, and reduced cell proliferation.
DR   Q2YDJ8, KMT5A_BOVIN;  Q22795, KMT5A_CAEEL;  Q9VFK6, KMT5A_DROME;
DR   Q297V5, KMT5A_DROPS;  Q9NQR1, KMT5A_HUMAN;  Q2YDW7, KMT5A_MOUSE;
DR   Q0V9E9, KMT5A_XENTR;  Q29RP8, KMT5B_BOVIN;  Q5U3H2, KMT5B_DANRE;
DR   Q4FZB7, KMT5B_HUMAN;  Q3U8K7, KMT5B_MOUSE;  P0C2N5, KMT5B_RAT  ;
DR   Q86Y97, KMT5C_HUMAN;  Q6Q783, KMT5C_MOUSE;  P0C2N6, KMT5C_RAT  ;
DR   A0JMZ4, KMT5C_XENLA;  Q071E0, KT5AA_DANRE;  Q08AY6, KT5AA_XENLA;
DR   Q498E6, KT5AB_XENLA;  Q6GP17, KT5BA_XENLA;  Q5RJX8, KT5BB_XENLA;
DR   A6QPM3, PRDM6_BOVIN;  Q9NQX0, PRDM6_HUMAN;  Q3UZD5, PRDM6_MOUSE;
DR   Q6P2A1, PRDM9_DANRE;  Q9NQV7, PRDM9_HUMAN;  Q96EQ9, PRDM9_MOUSE;
DR   P0C6Y7, PRDM9_RAT  ;  Q9W5E0, SUV42_DROME;
//