ENZYME entry: EC 2.1.1.365
Accepted Name |
MMP 1-O-methyltransferase.
|
Alternative Name(s) |
3-O-methylmannose polysaccharide 1-O-methyltransferase. |
Reaction catalysed |
S-adenosyl-L-methionine + 3,3'-di-O-methyl-4-alpha-mannobiose <=> S-adenosyl-L-homocysteine + 1,3,3'-tri-O-methyl-4-alpha-mannobiose |
Comment(s) |
- Requires Mg(2+).
- The enzyme, characterized from the bacterium Mycolicibacterium
hassiacum, participates in the biosynthesis of 3-O-methylmannose
polysaccharides (MMP), which are intracellular polymethylated
polysaccharides implicated in the modulation of fatty acid metabolism
in nontuberculous mycobacteria.
- The methylation catalyzed by this enzyme was shown to block the
reducing end of 3,3'-di-O-methyl-alpha-mannobiose, a probable early
precursor of the 3-O-methylmannose polysaccharides.
|
Cross-references |
BRENDA | 2.1.1.365 |
EC2PDB | 2.1.1.365 |
ExplorEnz | 2.1.1.365 |
PRIAM enzyme-specific profiles | 2.1.1.365 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.365 |
IUBMB Enzyme Nomenclature | 2.1.1.365 |
IntEnz | 2.1.1.365 |
MEDLINE | Find literature relating to 2.1.1.365 |
MetaCyc | 2.1.1.365 |
Rhea expert-curated reactions | 2.1.1.365 |
UniProtKB/Swiss-Prot |
|
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