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ENZYME entry: EC 2.1.1.365

Accepted Name
MMP 1-O-methyltransferase.
Alternative Name(s)
3-O-methylmannose polysaccharide 1-O-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + 3,3'-di-O-methyl-4-alpha-mannobiose <=> S-adenosyl-L-homocysteine + 1,3,3'-tri-O-methyl-4-alpha-mannobiose
Comment(s)
  • Requires Mg(2+).
  • The enzyme, characterized from the bacterium Mycolicibacterium hassiacum, participates in the biosynthesis of 3-O-methylmannose polysaccharides (MMP), which are intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism in nontuberculous mycobacteria.
  • The methylation catalyzed by this enzyme was shown to block the reducing end of 3,3'-di-O-methyl-alpha-mannobiose, a probable early precursor of the 3-O-methylmannose polysaccharides.
Cross-references
BRENDA2.1.1.365
EC2PDB2.1.1.365
ExplorEnz2.1.1.365
PRIAM enzyme-specific profiles2.1.1.365
KEGG Ligand Database for Enzyme Nomenclature2.1.1.365
IUBMB Enzyme Nomenclature2.1.1.365
IntEnz2.1.1.365
MEDLINEFind literature relating to 2.1.1.365
MetaCyc2.1.1.365
Rhea expert-curated reactions2.1.1.365
UniProtKB/Swiss-Prot
K5B7F3, MET1_MYCHD

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