ID   2.1.1.366
DE   [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
CA   N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine =
CA   H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-
CA   homocysteine.
CC   -!- The enzyme methylates only dimethylated lysine(9) of histone H3
CC       (H3K9), forming the trimethylated form.
CC   -!- This modification influences the binding of chromatin-associated
CC       proteins.
CC   -!- In general, the methylation of H3K9 leads to transcriptional
CC       repression of the affected target genes.
CC   -!- The enzyme is highly up-regulated in Huntington disease patients. cf.
CC       EC 2.1.1.355, EC 2.1.1.367, and EC 2.1.1.368.
DR   O60016, CLR4_SCHPO ;  G5EEU2, SET25_CAEEL;  O17679, SET6_CAEEL ;
DR   Q15047, SETB1_HUMAN;  O88974, SETB1_MOUSE;  Q6INA9, SETB1_XENLA;
DR   Q06ZW3, SETB2_DANRE;  Q96T68, SETB2_HUMAN;  Q8C267, SETB2_MOUSE;
DR   Q6YI93, SETB2_XENLA;  A4IGY9, SETB2_XENTR;  Q8W595, SUVR4_ARATH;
DR   Q6DGD3, SV91A_DANRE;
//